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dc.contributor.authorAverbeck, D
dc.contributor.authorBensasson, R V
dc.contributor.authorBuisson, J
dc.contributor.authorLand, Edward J
dc.contributor.authorRene, L
dc.contributor.authorRoyer, R
dc.contributor.authorSantus, R
dc.date.accessioned2011-05-13T14:52:37Z
dc.date.available2011-05-13T14:52:37Z
dc.date.issued1982-10
dc.identifier.citationPulse radiolysis and cellular studies of a new class of radiosensitizers: 2-nitrobenzofurans. 1982, 42 (4):457-68 Int. J Radiat Biol Relat Stud Phys Chem Meden
dc.identifier.issn0020-7616
dc.identifier.pmid6757163
dc.identifier.doi10.1080/09553008214551371
dc.identifier.urihttp://hdl.handle.net/10541/129503
dc.description.abstractA group of 2-nitrobenzofurans possessing antibacterial and antiparasitic properties have now been shown to be potential radiosensitizers from investigations in simple aqueous solution by pulse radiolysis and from survival studies in yeast. The radical anions of several 2-nitrobenzofurans were formed by the rapid reaction of the parent molecules with hydrated electrons or with various pyrimidine electron adducts. Studies of equilibria between these radical anions, the parent nitrobenzofurans and the corresponding species derived from quinones with known one-electron reduction potentials, showed that the one-electron reduction potentials of all the furans under investigation lie between -285 and -309 mV. They are thus more electron affinic than the nitroimidazoles (misonidazole and metronidazole) currently under clinical evaluation. 5-Hydroxy- and 7-hydroxy-2-nitrobenzofuran were demonstrated to form weak complexes with DNA (binding constant 80 M-1) and strong complexes with HSA (binding constant 10(5)M-1). In the yeast Saccharomyces cerevisiae the nitrobenzofurans exert radiosensitizing effects on survival either similar to or higher than misonidazole.
dc.language.isoenen
dc.subject.meshBenzofurans
dc.subject.meshCell Survival
dc.subject.meshDNA
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshNitrofurans
dc.subject.meshOxidation-Reduction
dc.subject.meshRadiation-Sensitizing Agents
dc.subject.meshSaccharomyces cerevisiae
dc.subject.meshSpectrophotometry
dc.subject.meshStructure-Activity Relationship
dc.titlePulse radiolysis and cellular studies of a new class of radiosensitizers: 2-nitrobenzofurans.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UKen
dc.identifier.journalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicineen
html.description.abstractA group of 2-nitrobenzofurans possessing antibacterial and antiparasitic properties have now been shown to be potential radiosensitizers from investigations in simple aqueous solution by pulse radiolysis and from survival studies in yeast. The radical anions of several 2-nitrobenzofurans were formed by the rapid reaction of the parent molecules with hydrated electrons or with various pyrimidine electron adducts. Studies of equilibria between these radical anions, the parent nitrobenzofurans and the corresponding species derived from quinones with known one-electron reduction potentials, showed that the one-electron reduction potentials of all the furans under investigation lie between -285 and -309 mV. They are thus more electron affinic than the nitroimidazoles (misonidazole and metronidazole) currently under clinical evaluation. 5-Hydroxy- and 7-hydroxy-2-nitrobenzofuran were demonstrated to form weak complexes with DNA (binding constant 80 M-1) and strong complexes with HSA (binding constant 10(5)M-1). In the yeast Saccharomyces cerevisiae the nitrobenzofurans exert radiosensitizing effects on survival either similar to or higher than misonidazole.


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