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dc.contributor.authorParkes, D J
dc.contributor.authorScott, David
dc.date.accessioned2011-04-17T08:42:08Z
dc.date.available2011-04-17T08:42:08Z
dc.date.issued1982
dc.identifier.citationA quantitative comparison of cytogenetic effects of anti-tumor agents. 1982, 33 (1-2):27-34 Cytogenet Cell Geneten
dc.identifier.issn0301-0171
dc.identifier.pmid7116938
dc.identifier.urihttp://hdl.handle.net/10541/128230
dc.description.abstractThe relative potency of different anti-tumor agents in inducing structural and numerical chromosome abnormalities and SCEs was assessed by making comparisons at equitoxic doses, measured in terms of colony forming ability, in cultured diploid human fibroblasts. At approximately 20% survival the relative potency of X-rays, daunorubicin, nitrogen mustard, adriamycin, and actinomycin D in inducing structural aberrations was 1.0, 0.85, 0.26, 0.22, and zero, respectively. SCE induction was quantitatively unrelated to the induction of chromosome aberrations. No numerical changes were observed. Accurate assessment of the yields of chromosome aberrations requires the use of multiple sampling times in asynchronous populations.
dc.language.isoenen
dc.subjectAnticancerous Agentsen
dc.subject.meshAntineoplastic Agents
dc.subject.meshCarcinogens
dc.subject.meshCell Survival
dc.subject.meshCells, Cultured
dc.subject.meshChromosome Aberrations
dc.subject.meshCrossing Over, Genetic
dc.subject.meshFibroblasts
dc.subject.meshHumans
dc.subject.meshMutagenicity Tests
dc.subject.meshMutagens
dc.subject.meshSister Chromatid Exchange
dc.titleA quantitative comparison of cytogenetic effects of anti-tumor agents.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UKen
dc.identifier.journalCytogenetics and Cell Geneticsen
html.description.abstractThe relative potency of different anti-tumor agents in inducing structural and numerical chromosome abnormalities and SCEs was assessed by making comparisons at equitoxic doses, measured in terms of colony forming ability, in cultured diploid human fibroblasts. At approximately 20% survival the relative potency of X-rays, daunorubicin, nitrogen mustard, adriamycin, and actinomycin D in inducing structural aberrations was 1.0, 0.85, 0.26, 0.22, and zero, respectively. SCE induction was quantitatively unrelated to the induction of chromosome aberrations. No numerical changes were observed. Accurate assessment of the yields of chromosome aberrations requires the use of multiple sampling times in asynchronous populations.


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