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    Production of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis.

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    Authors
    Dunn, C
    Jones, J
    Lange, R
    Wright, Eric G
    Moore, M
    Affiliation
    The Department of Medical Biology, Memorial Research Center, The University of Tennessee College of Medicine, Knoxville Units.
    Issue Date
    1982-01
    
    Metadata
    Show full item record
    Abstract
    Conditioned media (CM) were prepared according to previously published techniques from the bone marrow of dogs with cyclic haematopoiesis (CH). CM prepared from day 9 marrows inhibited mouse bone marrow CFU-s proliferation rate while CM from day 10 marrows were stimulatory and also contained an erythroid stimulating factor which appeared to be erythropoietin. In addition a highly significant trend from CM containing CFU-s inhibitory materials to media with CFU-s stimulatory activity was observed through cycles day 1 to 8. These studies further support the concept that CH is due to a defect in factors controlling stem cell proliferation and suggest that a major event occurs in CH dog marrow on days 9 and/or 10 of the cycle.
    Citation
    Production of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis. 1982, 15 (1):1-10 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/125379
    PubMed ID
    7060078
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    Collections
    All Paterson Institute for Cancer Research

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