Production of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis.
AffiliationThe Department of Medical Biology, Memorial Research Center, The University of Tennessee College of Medicine, Knoxville Units.
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AbstractConditioned media (CM) were prepared according to previously published techniques from the bone marrow of dogs with cyclic haematopoiesis (CH). CM prepared from day 9 marrows inhibited mouse bone marrow CFU-s proliferation rate while CM from day 10 marrows were stimulatory and also contained an erythroid stimulating factor which appeared to be erythropoietin. In addition a highly significant trend from CM containing CFU-s inhibitory materials to media with CFU-s stimulatory activity was observed through cycles day 1 to 8. These studies further support the concept that CH is due to a defect in factors controlling stem cell proliferation and suggest that a major event occurs in CH dog marrow on days 9 and/or 10 of the cycle.
CitationProduction of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis. 1982, 15 (1):1-10 Cell Tissue Kinet
JournalCell and Tissue Kinetics
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