Production of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis.
Affiliation
The Department of Medical Biology, Memorial Research Center, The University of Tennessee College of Medicine, Knoxville Units.Issue Date
1982-01
Metadata
Show full item recordAbstract
Conditioned media (CM) were prepared according to previously published techniques from the bone marrow of dogs with cyclic haematopoiesis (CH). CM prepared from day 9 marrows inhibited mouse bone marrow CFU-s proliferation rate while CM from day 10 marrows were stimulatory and also contained an erythroid stimulating factor which appeared to be erythropoietin. In addition a highly significant trend from CM containing CFU-s inhibitory materials to media with CFU-s stimulatory activity was observed through cycles day 1 to 8. These studies further support the concept that CH is due to a defect in factors controlling stem cell proliferation and suggest that a major event occurs in CH dog marrow on days 9 and/or 10 of the cycle.Citation
Production of presumptive humoral haematopoietic regulators in canine cyclic haematopoiesis. 1982, 15 (1):1-10 Cell Tissue KinetJournal
Cell and Tissue KineticsPubMed ID
7060078Type
ArticleLanguage
enISSN
0008-8730Collections
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