Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice.
Affiliation
Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UKIssue Date
1982
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The enhanced repair of O6-methylguanine from hepatic DNA in rats is a well established phenomenon that can be induced by pretreatment with a variety of hepatotoxic agents as well as by partial hepatectomy. Attempts to induce a similar hepatic response by treatment with single doses of aflatoxin B1 in C57Bl mice, single doses of dimethylnitrosamine (DMN) in C57Bl or BALB/C mice or by prolonged pretreatment with DMN by addition to the drinking water of C57Bl mice were uniformly unsuccessful. Furthermore, the intense proliferative response induced by two-thirds partial hepatectomy in C57Bl mice was also apparently incapable of increasing the activity of this repair function. These experiments, in which repair of O6-methylguanine has been determined both in vivo after administration of [14C]DMN and in vitro using crude tissue extracts and a methylated DNA substrate, indicate the presence of an intergeneric difference between rats and mice with respect to this repair function.Citation
Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice. 1982, 3 (11):1247-54 CarcinogenesisJournal
CarcinogenesisDOI
10.1093/carcin/3.11.1247PubMed ID
6817935Type
ArticleLanguage
enISSN
0143-3334ae974a485f413a2113503eed53cd6c53
10.1093/carcin/3.11.1247
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