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    Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice.

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    Authors
    Maru, G B
    Margison, Geoffrey P
    Chu, Y
    O'Connor, Peter J
    Affiliation
    Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UK
    Issue Date
    1982
    
    Metadata
    Show full item record
    Abstract
    The enhanced repair of O6-methylguanine from hepatic DNA in rats is a well established phenomenon that can be induced by pretreatment with a variety of hepatotoxic agents as well as by partial hepatectomy. Attempts to induce a similar hepatic response by treatment with single doses of aflatoxin B1 in C57Bl mice, single doses of dimethylnitrosamine (DMN) in C57Bl or BALB/C mice or by prolonged pretreatment with DMN by addition to the drinking water of C57Bl mice were uniformly unsuccessful. Furthermore, the intense proliferative response induced by two-thirds partial hepatectomy in C57Bl mice was also apparently incapable of increasing the activity of this repair function. These experiments, in which repair of O6-methylguanine has been determined both in vivo after administration of [14C]DMN and in vitro using crude tissue extracts and a methylated DNA substrate, indicate the presence of an intergeneric difference between rats and mice with respect to this repair function.
    Citation
    Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice. 1982, 3 (11):1247-54 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/125378
    DOI
    10.1093/carcin/3.11.1247
    PubMed ID
    6817935
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/3.11.1247
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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