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    Repair of DNA interstrand crosslinks after busulphan. A possible mode of resistance.

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    Authors
    Bedford, P
    Fox, Brian W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, United Kingdom
    Issue Date
    1982
    
    Metadata
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    Abstract
    The technique of alkaline elution has been used to study the interaction between the antineoplastic drug busulphan and the DNA of cells derived from the transplantable rodent Yoshida sarcoma. A dose-dependent proteinase-resistant filter retention was observed after drug treatment, which indicated the presence of DNA interstrand cross-links. Such cross-links were removed after 6 h in cells resistant to busulphan but not in the busulphan-sensitive parent cells, even after 24 h. Such temporal differences in DNA cross-linking could be correlated with cell survival and also with the level of anaphase chromosome aberrations, which was found to be four-fold higher in the sensitive line than in the resistant line.
    Citation
    Repair of DNA interstrand crosslinks after busulphan. A possible mode of resistance. 1982, 8 (1):3-7 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/125372
    DOI
    10.1007/BF00292863
    PubMed ID
    7094199
    Type
    Article
    Language
    en
    ISSN
    0344-5704
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00292863
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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