• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Human bronchoalveolar macrophage cytotoxicity for cultured human lung-tumour cells.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Swinburne, S
    Moore, Michael
    Cole, P
    Affiliation
    Host Defence Unit, Deaprtment of Medicine, Cardiothoraci Institute, Brompton Hospital, Fulham Road, London SW3 6HP.
    Issue Date
    1982-10
    
    Metadata
    Show full item record
    Abstract
    Human bronchoalveolar macrophages were separated from other free lung cells by density sedimentation on Percoll gradients. They were then tested for cytotoxicity against the human lung adenocarcinoma cell line A549, using a Selenomethionine-75 post-labelling assay. The cytotoxicity of the macrophages increased as the effector:target cell ratio was increased, approaching 100% at 20:1. There was no significant difference in the cytotoxicity of macrophages isolated from the lungs of bronchial-carcinoma or non-carcinoma patients. The highly cytotoxic nature of the macrophages was not due to selection of a more potent cytotoxic subpopulation of macrophages on the Percoll gradient, nor to a generally elevated activation of the macrophages due to the pathological conditions in the patients' lungs. An attempt to determine whether low concentrations of macrophages could potentiate target-cell growth proved negative. Cytotoxicity of macrophages for cultured lung target cells was not restricted to A549 cells and is not in accordance with the view that defective bronchoalveolar macrophage cytotoxicity contributes to the emergence of bronchial neoplasia.
    Citation
    Human bronchoalveolar macrophage cytotoxicity for cultured human lung-tumour cells. 1982, 46 (4):625-34 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/125371
    PubMed ID
    7138768
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Human peripheral blood monocyte and bronchoalveolar macrophage cytotoxicity for cultured human lung tumor cells.
    • Authors: Swinburne S, Cole P
    • Issue date: 1982 Nov
    • Bronchoalveolar lavage and the immunology of primary lung cancer.
    • Authors: Olsen GN, Gangemi JD
    • Issue date: 1985 May
    • [Determination of macrophage activity in bronchoalveolar lavage fluid in patients with lung diseases].
    • Authors: Ochendalski M, Müller S, Unger U, Grollmuss H, Schilling W
    • Issue date: 1987
    • Lymphokine-activated killer cell activity in lung cancer.
    • Authors: LeFever A, Funahashi A
    • Issue date: 1991 Feb
    • Phagocytic activity of alveolar macrophages in patients with bronchogenic carcinoma.
    • Authors: Gangemi JD, Olsen GN, Fechter C, Hightower JA, Bauguess CT, Krech L
    • Issue date: 1985
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.