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dc.contributor.authorHaworth, C
dc.contributor.authorMorris-Jones, P
dc.contributor.authorTesta, Nydia G
dc.date.accessioned2011-03-22T17:03:33Z
dc.date.available2011-03-22T17:03:33Z
dc.date.issued1982-12
dc.identifier.citationLong-term bone-marrow damage in children treated for ALL: evidence from in vitro colony assays (GM-CFC and CFUF). 1982, 46 (6):918-23 Br J Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid6960924
dc.identifier.urihttp://hdl.handle.net/10541/125369
dc.description.abstractWe have studied granulocyte-macrophage progenitor cells (GM-CFC) in serial bone marrow aspirates from 43 children who had been treated for acute lymphoblastic leukaemia (ALL). All patients were in full remission, not receiving anti-leukaemic therapy and 42 out of the 43 had normal peripheral blood counts. Thirty-seven patients have received standard amounts of chemotherapy and 6 have received additional therapy for relapses occurring in the first treatment-free interval. In the former group estimation of GM-CFC incidence did not provide evidence of long-term residual bone-marrow damage. In the latter, however, the mean incidence of GM-CFC was significantly reduced. This reduction was also apparent when the incidence of GM-CFC was related to the incidence of non-haemopoietic progenitor cells within the marrow (CFU-F).
dc.language.isoenen
dc.subjectAnticancerous Agentsen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectHaemoglobinsen
dc.subjectLymphoid Leukaemiaen
dc.subject.meshAntineoplastic Agents
dc.subject.meshBone Marrow
dc.subject.meshBone Marrow Diseases
dc.subject.meshChild
dc.subject.meshColony-Forming Units Assay
dc.subject.meshFollow-Up Studies
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshHemoglobins
dc.subject.meshHumans
dc.subject.meshLeukemia, Lymphoid
dc.subject.meshLeukocyte Count
dc.subject.meshNeutrophils
dc.subject.meshPlatelet Count
dc.titleLong-term bone-marrow damage in children treated for ALL: evidence from in vitro colony assays (GM-CFC and CFUF).en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UKen
dc.identifier.journalBritish Journal of Canceren
html.description.abstractWe have studied granulocyte-macrophage progenitor cells (GM-CFC) in serial bone marrow aspirates from 43 children who had been treated for acute lymphoblastic leukaemia (ALL). All patients were in full remission, not receiving anti-leukaemic therapy and 42 out of the 43 had normal peripheral blood counts. Thirty-seven patients have received standard amounts of chemotherapy and 6 have received additional therapy for relapses occurring in the first treatment-free interval. In the former group estimation of GM-CFC incidence did not provide evidence of long-term residual bone-marrow damage. In the latter, however, the mean incidence of GM-CFC was significantly reduced. This reduction was also apparent when the incidence of GM-CFC was related to the incidence of non-haemopoietic progenitor cells within the marrow (CFU-F).


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