Long-term bone-marrow damage in children treated for ALL: evidence from in vitro colony assays (GM-CFC and CFUF).
AffiliationPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK
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AbstractWe have studied granulocyte-macrophage progenitor cells (GM-CFC) in serial bone marrow aspirates from 43 children who had been treated for acute lymphoblastic leukaemia (ALL). All patients were in full remission, not receiving anti-leukaemic therapy and 42 out of the 43 had normal peripheral blood counts. Thirty-seven patients have received standard amounts of chemotherapy and 6 have received additional therapy for relapses occurring in the first treatment-free interval. In the former group estimation of GM-CFC incidence did not provide evidence of long-term residual bone-marrow damage. In the latter, however, the mean incidence of GM-CFC was significantly reduced. This reduction was also apparent when the incidence of GM-CFC was related to the incidence of non-haemopoietic progenitor cells within the marrow (CFU-F).
CitationLong-term bone-marrow damage in children treated for ALL: evidence from in vitro colony assays (GM-CFC and CFUF). 1982, 46 (6):918-23 Br J Cancer
JournalBritish Journal of Cancer
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