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dc.contributor.authorFrassoni, F
dc.contributor.authorTesta, Nydia G
dc.contributor.authorLord, Brian I
dc.date.accessioned2011-03-22T17:21:10Z
dc.date.available2011-03-22T17:21:10Z
dc.date.issued1982-07
dc.identifier.citationThe relative spatial distribution of erythroid progenitor cells (BFUe and CFUe) in the normal mouse femur. 1982, 15 (4):447-55 Cell Tissue Kineten
dc.identifier.issn0008-8730
dc.identifier.pmid7105134
dc.identifier.urihttp://hdl.handle.net/10541/125357
dc.description.abstractFemoral mouse bone marrow cells were separated into axial and marginal fractions, in order to investigate the relative concentration of erythroid progenitor cells (BFUe and CFUe) with respect to their location across the diameter of the femur. Two areas of high incidence of early progenitor cells (BFUe) were identified: one lying near the bone surface with a peak at about 410 micrometers radial distance from the axis of the bone; the other nearer the centre of the bone with a peak at about 270 micrometers. The more immature BFUe were found in higher proportion in the marginal peak. In contrast, CFUe, apart from very low concentration values in the vicinity of the bone surface, demonstrated a fairly uniform distribution throughout the marrow. The present results indicate that the distribution of erythroid progenitor cells within the bone marrow is not random. The haemopoietic tissue seems to exhibit a well-defined structure that may be relevant in regulating proliferation and differentiation processes.
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals
dc.subject.meshBone Marrow Cells
dc.subject.meshCell Separation
dc.subject.meshColony-Forming Units Assay
dc.subject.meshErythrocytes
dc.subject.meshErythropoiesis
dc.subject.meshFemur
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMice, Inbred C57BL
dc.titleThe relative spatial distribution of erythroid progenitor cells (BFUe and CFUe) in the normal mouse femur.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, CHristie Hospital and Holt Radium Institute, Withington, Manchester, M20 9BX, UKen
dc.identifier.journalCell and Tissue Kineticsen
html.description.abstractFemoral mouse bone marrow cells were separated into axial and marginal fractions, in order to investigate the relative concentration of erythroid progenitor cells (BFUe and CFUe) with respect to their location across the diameter of the femur. Two areas of high incidence of early progenitor cells (BFUe) were identified: one lying near the bone surface with a peak at about 410 micrometers radial distance from the axis of the bone; the other nearer the centre of the bone with a peak at about 270 micrometers. The more immature BFUe were found in higher proportion in the marginal peak. In contrast, CFUe, apart from very low concentration values in the vicinity of the bone surface, demonstrated a fairly uniform distribution throughout the marrow. The present results indicate that the distribution of erythroid progenitor cells within the bone marrow is not random. The haemopoietic tissue seems to exhibit a well-defined structure that may be relevant in regulating proliferation and differentiation processes.


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