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    A long-lived thymidine pool in epithelial stem cells.

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    Authors
    Hume, W J
    Potten, Christopher S
    Affiliation
    Paterson laboratories, Christie Hospital and Holt Radium Institute, Manchester, England.
    Issue Date
    1982-01
    
    Metadata
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    Abstract
    The labelling index (LI) of the individual basal cell positions of the anterior column of mouse tongue filiform papillae was assessed with time after an injection of [3H]TdR at 12.00 hours (the minimum point in the circadian LI rhythm). An initial doubling of the LI in the stem cell zone due to cell division was followed by a second rise of 14-16% 16 hr after injection and this occurred even in the presence of vincristine. Although the uptake of [3H]TdR and the initial LI doubling were largely prevented by a preceding injection of hydroxyurea, the 14-16% LI rise was still observed. The possible explanations are discussed, the favoured one being that an average of one of the six or seven cells (the stem cell) in each stem cell zone can store [3H]TdR in a long-lived precursor pool for at least 16 hr before being utilized for DNA synthesis. This complements previously published work which suggested that one cell in each stem cell zone may selectively segregate DNA at mitosis.
    Citation
    A long-lived thymidine pool in epithelial stem cells. 1982, 15 (1):49-58 Cell Tissue Kinet
    Journal
    Cell and Tissue Kinetics
    URI
    http://hdl.handle.net/10541/125349
    PubMed ID
    7060082
    Type
    Article
    Language
    en
    ISSN
    0008-8730
    Collections
    All Paterson Institute for Cancer Research

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