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    Differential effect of IP- and IV-injected nitrogen mustard on subsequently-irradiated intestinal crypts: implications for 'dose-effect factors' predicted by experimental, combined modality therapy.

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    Authors
    Moore, James V
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UK
    Issue Date
    1984-05
    
    Metadata
    Show full item record
    Abstract
    In experimental chemotherapy-radiotherapy, cytotoxic drugs are almost invariably injected by the intraperitoneal (IP) route. This contrasts with normal clinical practice, which is to employ the intravenous (IV) route. We have used a clonogenic assay of gastrointestinal (GI) injury in mice to show that a given administered dose of nitrogen mustard (HN2), injected IP, results in a much greater reduction in the subsequent radiation dose required to achieve an isoeffect, than if the drug is injected IV. At an administered dose of 3.5 mg kg-1 of HN2 (the animal LD10/30 for IP injection), the radiation dose-reduction factor for 10% survival of intestinal crypts, was 1.94 for IP HN2 and only 1.28 for IV HN2. Even the grossly-equitoxic (mouse LD10/30) dose of IV HN2 resulted in a smaller predicted radiation dose reduction for GI injury, by a factor of 1.45. The validity of using the IP route in combined chemotherapy-radiotherapy studies designed to generate quantitative estimates of toxicity is discussed.
    Citation
    Differential effect of IP- and IV-injected nitrogen mustard on subsequently-irradiated intestinal crypts: implications for 'dose-effect factors' predicted by experimental, combined modality therapy. 1984, 57 (677):403-7 Br J Radiol
    Journal
    The British journal of Radiology
    URI
    http://hdl.handle.net/10541/124432
    DOI
    10.1259/0007-1285-57-677-403
    PubMed ID
    6722435
    Type
    Article
    Language
    en
    ISSN
    0007-1285
    EISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/0007-1285-57-677-403
    Scopus Count
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    All Paterson Institute for Cancer Research

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