Show simple item record

dc.contributor.authorHoey, Brigid M
dc.contributor.authorButler, John
dc.date.accessioned2011-03-13T00:03:10Z
dc.date.available2011-03-13T00:03:10Z
dc.date.issued1984-12-07
dc.identifier.citationThe repair of oxidized amino acids by antioxidants. 1984, 791 (2):212-8 Biochim Biophys Actaen
dc.identifier.issn0006-3002
dc.identifier.pmid6509064
dc.identifier.doi10.1016/0167-4838(84)90011-6
dc.identifier.urihttp://hdl.handle.net/10541/124424
dc.description.abstractNatural and synthetic antioxidants have been shown to repair tryptophan radicals produced from the one-electron oxidation of the free tryptophan amino acid. It has also been observed that both tryptophan and tyrosine radicals in lysozyme can be repaired by these antioxidants to varying degrees of efficiency. Although SDS-solubilized alpha-tocopherol efficiently repairs free tryptophan radicals, it is very inefficient in repairing the amino acids in lysozyme. The rigidity and immobility of solubilized alpha-tocopherol can explain this lack of efficiency.
dc.language.isoenen
dc.subject.meshAntioxidants
dc.subject.meshAscorbic Acid
dc.subject.meshAzides
dc.subject.meshFree Radicals
dc.subject.meshMuramidase
dc.subject.meshOxidation-Reduction
dc.subject.meshSpectrophotometry
dc.subject.meshTryptophan
dc.subject.meshTyrosine
dc.subject.meshUric Acid
dc.subject.meshVitamin E
dc.titleThe repair of oxidized amino acids by antioxidants.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UKen
dc.identifier.journalBiochimica et Biophysica Actaen
html.description.abstractNatural and synthetic antioxidants have been shown to repair tryptophan radicals produced from the one-electron oxidation of the free tryptophan amino acid. It has also been observed that both tryptophan and tyrosine radicals in lysozyme can be repaired by these antioxidants to varying degrees of efficiency. Although SDS-solubilized alpha-tocopherol efficiently repairs free tryptophan radicals, it is very inefficient in repairing the amino acids in lysozyme. The rigidity and immobility of solubilized alpha-tocopherol can explain this lack of efficiency.


Files in this item

This item appears in the following Collection(s)

Show simple item record