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    Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker.

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    Authors
    Canney, Peter A
    Moore, Michael
    Wilkinson, Peter M
    James, Roger D
    Affiliation
    Paterson Laboratories and Radiotherapy Department, CHristie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1984-12
    
    Metadata
    Show full item record
    Abstract
    Serum CA 125, quantified by an immunoradiometric assay employing the monoclonal antibody 0C125 was found to be elevated in 48/58 (83%) of patients with established ovarian cancer. All histological types of carcinoma were antigen positive and there was a positive correlation between the frequency and level of serum CA125 and body burden of tumour. Twenty patients undergoing chemotherapy had serial CA125 estimations following a prospective protocol. Variation in CA125 level reflected disease progression or regression in 21/23 instances. Three of 9 patients tested showed an acute elevation of CA125 in the first week following chemotherapy and this effect predicted a good response to treatment. The natural half-life of CA125 in serum was estimated at approximately 4.8 days, sufficiently short to allow changes in tumour volume to be rapidly reflected by a change in circulating antigen level. Although none of 15 patients with non-Hodgkin lymphoma demonstrated antigen levels outside the normal range, 11/27 patients with non-ovarian adenocarcinoma showed elevated CA125 levels, a specificity of 58% for this latter group. The value of CA125 in the management of ovarian malignancy is discussed.
    Citation
    Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker. 1984, 50 (6):765-9 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/124420
    PubMed ID
    6208925
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications

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