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    Oral acyclovir prophylaxis against herpes simplex virus in non-Hodgkin lymphoma and acute lymphoblastic leukaemia patients receiving remission induction chemotherapy. A randomised double blind, placebo controlled trial.

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    Authors
    Anderson, Heather
    Scarffe, J Howard
    Sutton, R N
    Hickmott, E
    Brigden, D
    Burke, C
    Affiliation
    The Department of Medical Oncology, Christie Hospital and Holt Radium Institute
    Issue Date
    1984-07
    
    Metadata
    Show full item record
    Abstract
    Forty-one patients receiving remission induction chemotherapy with vincristine, adriamycin and prednisolone (VAP) for high grade lymphoma or acute lymphoblastic leukaemia were entered into a double blind, placebo controlled trial of oral acyclovir prophylaxis against herpes simplex virus (HSV) infection. The dose of acyclovir was 200 mg four times daily for the duration of chemotherapy (six weeks). Of the 40 evaluable patients, 20 were randomised to each arm. Prophylactic oral acyclovir significantly reduced the incidence of clinical HSV infection from 60% on placebo to 5% acyclovir (P less than 0.001), and the incidence of viral isolates from 70% on placebo to 5% on acyclovir (P less than 0.001).
    Citation
    Oral acyclovir prophylaxis against herpes simplex virus in non-Hodgkin lymphoma and acute lymphoblastic leukaemia patients receiving remission induction chemotherapy. A randomised double blind, placebo controlled trial. 1984, 50 (1):45-9 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/124412
    PubMed ID
    6378236
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    EISSN
    1532-1827
    Collections
    All Christie Publications

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