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dc.contributor.authorRankin, E M
dc.contributor.authorJones, D M
dc.contributor.authorLawston, F G
dc.contributor.authorKane, R J
dc.contributor.authorScarffe, J Howard
dc.date.accessioned2011-03-12T23:33:00Z
dc.date.available2011-03-12T23:33:00Z
dc.date.issued1984-10
dc.identifier.citationObservations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia. 1984, 14 (4):411-21 J Antimicrob Chemotheren
dc.identifier.issn0305-7453
dc.identifier.pmid6238929
dc.identifier.doi10.1093/jac/14.4.411
dc.identifier.urihttp://hdl.handle.net/10541/124411
dc.description.abstractIn a retrospective study we have compared the toxic side effects related to the use of two antibiotic regimens in the treatment of febrile episodes in neutropenic, leukaemic patients undergoing first remission-induction. Nephrotoxicity was more severe in the gentamicin-mezlocillin (G/M) group: four patients developed oliguric renal failure and two others showed rises in the serum creatinine of more than 0.03 mmol/l. One of the two patients in the gentamicin-ticarcillin (G/T) group who showed nephrotoxicity developed renal failure. Ototoxicity and skin rashes were more commonly observed with G/M than with G/T, and the differences were statistically significant for both ototoxicity (P = 0.0004) and drug rashes (P = 0.02). The cause of the observed differences in toxicity has not been identified.
dc.language.isoenen
dc.subject.meshAcute Disease
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshDrug Combinations
dc.subject.meshDrug Eruptions
dc.subject.meshEar
dc.subject.meshFemale
dc.subject.meshGentamicins
dc.subject.meshHumans
dc.subject.meshKidney
dc.subject.meshLeukemia
dc.subject.meshMale
dc.subject.meshMezlocillin
dc.subject.meshMiddle Aged
dc.subject.meshTicarcillin
dc.titleObservations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Guy's Hospital, London SE1 9RTen
dc.identifier.journalThe Journal of Antimicrobial Chemotherapyen
html.description.abstractIn a retrospective study we have compared the toxic side effects related to the use of two antibiotic regimens in the treatment of febrile episodes in neutropenic, leukaemic patients undergoing first remission-induction. Nephrotoxicity was more severe in the gentamicin-mezlocillin (G/M) group: four patients developed oliguric renal failure and two others showed rises in the serum creatinine of more than 0.03 mmol/l. One of the two patients in the gentamicin-ticarcillin (G/T) group who showed nephrotoxicity developed renal failure. Ototoxicity and skin rashes were more commonly observed with G/M than with G/T, and the differences were statistically significant for both ototoxicity (P = 0.0004) and drug rashes (P = 0.02). The cause of the observed differences in toxicity has not been identified.


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