Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia.
dc.contributor.author | Rankin, E M | |
dc.contributor.author | Jones, D M | |
dc.contributor.author | Lawston, F G | |
dc.contributor.author | Kane, R J | |
dc.contributor.author | Scarffe, J Howard | |
dc.date.accessioned | 2011-03-12T23:33:00Z | |
dc.date.available | 2011-03-12T23:33:00Z | |
dc.date.issued | 1984-10 | |
dc.identifier.citation | Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia. 1984, 14 (4):411-21 J Antimicrob Chemother | en |
dc.identifier.issn | 0305-7453 | |
dc.identifier.pmid | 6238929 | |
dc.identifier.doi | 10.1093/jac/14.4.411 | |
dc.identifier.uri | http://hdl.handle.net/10541/124411 | |
dc.description.abstract | In a retrospective study we have compared the toxic side effects related to the use of two antibiotic regimens in the treatment of febrile episodes in neutropenic, leukaemic patients undergoing first remission-induction. Nephrotoxicity was more severe in the gentamicin-mezlocillin (G/M) group: four patients developed oliguric renal failure and two others showed rises in the serum creatinine of more than 0.03 mmol/l. One of the two patients in the gentamicin-ticarcillin (G/T) group who showed nephrotoxicity developed renal failure. Ototoxicity and skin rashes were more commonly observed with G/M than with G/T, and the differences were statistically significant for both ototoxicity (P = 0.0004) and drug rashes (P = 0.02). The cause of the observed differences in toxicity has not been identified. | |
dc.language.iso | en | en |
dc.subject.mesh | Acute Disease | |
dc.subject.mesh | Adolescent | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Drug Combinations | |
dc.subject.mesh | Drug Eruptions | |
dc.subject.mesh | Ear | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gentamicins | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Kidney | |
dc.subject.mesh | Leukemia | |
dc.subject.mesh | Male | |
dc.subject.mesh | Mezlocillin | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Ticarcillin | |
dc.title | Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia. | en |
dc.type | Article | en |
dc.contributor.department | Department of Medical Oncology, Guy's Hospital, London SE1 9RT | en |
dc.identifier.journal | The Journal of Antimicrobial Chemotherapy | en |
html.description.abstract | In a retrospective study we have compared the toxic side effects related to the use of two antibiotic regimens in the treatment of febrile episodes in neutropenic, leukaemic patients undergoing first remission-induction. Nephrotoxicity was more severe in the gentamicin-mezlocillin (G/M) group: four patients developed oliguric renal failure and two others showed rises in the serum creatinine of more than 0.03 mmol/l. One of the two patients in the gentamicin-ticarcillin (G/T) group who showed nephrotoxicity developed renal failure. Ototoxicity and skin rashes were more commonly observed with G/M than with G/T, and the differences were statistically significant for both ototoxicity (P = 0.0004) and drug rashes (P = 0.02). The cause of the observed differences in toxicity has not been identified. |