Show simple item record

dc.contributor.authorDurning, P
dc.contributor.authorSchor, Seth L
dc.contributor.authorSellwood, R A
dc.date.accessioned2011-03-12T23:17:36Z
dc.date.available2011-03-12T23:17:36Z
dc.date.issued1984-10-20
dc.identifier.citationFibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro. 1984, 2 (8408):890-2 Lanceten
dc.identifier.issn0140-6736
dc.identifier.pmid6148619
dc.identifier.doi10.1016/S0140-6736(84)90653-6
dc.identifier.urihttp://hdl.handle.net/10541/124407
dc.description.abstractIn culture on collagen gels normal and transformed fibroblasts can be distinguished by their differential migratory response to changes in cell density. The effects of cell density on fibroblast migration may be expressed by a single numerical value, the cell density migration index (CDMI). Tumour-derived fibroblasts and skin fibroblasts from the majority of 24 breast-cancer patients examined had CDMI values characteristic of transformed cells. There was a significant correlation between the expression of abnormal CDMI values by tumour-derived fibroblasts and the presence of lymph-node metastases. Fibroblasts from 10 patients with benign breast disease had normal CDMI values.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshBreast Diseases
dc.subject.meshBreast Neoplasms
dc.subject.meshCarcinoma, Intraductal, Noninfiltrating
dc.subject.meshCell Count
dc.subject.meshCell Movement
dc.subject.meshCells, Cultured
dc.subject.meshCollagen
dc.subject.meshFibroblasts
dc.subject.meshGels
dc.subject.meshHumans
dc.subject.meshLymphatic Metastasis
dc.subject.meshMiddle Aged
dc.subject.meshSkin
dc.titleFibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro.en
dc.typeArticleen
dc.identifier.eissn1474-547X
dc.contributor.departmentNorth Manchester General Hospital, Manchester, United Kingdom.en
dc.identifier.journalLanceten
html.description.abstractIn culture on collagen gels normal and transformed fibroblasts can be distinguished by their differential migratory response to changes in cell density. The effects of cell density on fibroblast migration may be expressed by a single numerical value, the cell density migration index (CDMI). Tumour-derived fibroblasts and skin fibroblasts from the majority of 24 breast-cancer patients examined had CDMI values characteristic of transformed cells. There was a significant correlation between the expression of abnormal CDMI values by tumour-derived fibroblasts and the presence of lymph-node metastases. Fibroblasts from 10 patients with benign breast disease had normal CDMI values.


Files in this item

This item appears in the following Collection(s)

Show simple item record