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    Fibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro.

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    Authors
    Durning, P
    Schor, Seth L
    Sellwood, R A
    Affiliation
    North Manchester General Hospital, Manchester, United Kingdom.
    Issue Date
    1984-10-20
    
    Metadata
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    Abstract
    In culture on collagen gels normal and transformed fibroblasts can be distinguished by their differential migratory response to changes in cell density. The effects of cell density on fibroblast migration may be expressed by a single numerical value, the cell density migration index (CDMI). Tumour-derived fibroblasts and skin fibroblasts from the majority of 24 breast-cancer patients examined had CDMI values characteristic of transformed cells. There was a significant correlation between the expression of abnormal CDMI values by tumour-derived fibroblasts and the presence of lymph-node metastases. Fibroblasts from 10 patients with benign breast disease had normal CDMI values.
    Citation
    Fibroblasts from patients with breast cancer show abnormal migratory behaviour in vitro. 1984, 2 (8408):890-2 Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/124407
    DOI
    10.1016/S0140-6736(84)90653-6
    PubMed ID
    6148619
    Type
    Article
    Language
    en
    ISSN
    0140-6736
    EISSN
    1474-547X
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(84)90653-6
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