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dc.contributor.authorHilton, A M
dc.contributor.authorHasleton, Philip S
dc.contributor.authorBradlow, A
dc.contributor.authorLeahy, B C
dc.contributor.authorCooper, K Michael
dc.contributor.authorMoore, M
dc.date.accessioned2011-03-13T00:25:44Z
dc.date.available2011-03-13T00:25:44Z
dc.date.issued1984-03
dc.identifier.citationCutaneous vasculitis and immune complexes in severe bronchiectasis. 1984, 39 (3):185-91 Thoraxen
dc.identifier.issn0040-6376
dc.identifier.pmid6710426
dc.identifier.doi10.1136/thx.39.3.185
dc.identifier.urihttp://hdl.handle.net/10541/124397
dc.description.abstractFour patients with severe bronchiectasis (chronic bronchial suppuration) are described who developed cutaneous lesions associated with exacerbations of their respiratory disease. The skin abnormalities consisted of purpuric lesions in three patients and an erythematous vasculitis in one. Circulating immune complexes were present in all patients and in three skin biopsy specimens showed deposition of C3, IgG, and IgA in dermal blood vessels. Haemophilus influenzae had been isolated from the sputum of all four patients and in two patients was present at the time the cutaneous lesions appeared. It is suggested that local immune complex deposition was responsible for the skin lesions which occurred during acute exacerbations of bronchiectasis.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAntigen-Antibody Complex
dc.subject.meshBronchiectasis
dc.subject.meshComplement C3
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoglobulins
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshVasculitis, Leukocytoclastic, Cutaneous
dc.titleCutaneous vasculitis and immune complexes in severe bronchiectasis.en
dc.typeArticleen
dc.identifier.eissn1468-3296
dc.contributor.departmentDepartments of Chest Medicine and Pathology, Wythenshawe Hospitalen
dc.identifier.journalThoraxen
html.description.abstractFour patients with severe bronchiectasis (chronic bronchial suppuration) are described who developed cutaneous lesions associated with exacerbations of their respiratory disease. The skin abnormalities consisted of purpuric lesions in three patients and an erythematous vasculitis in one. Circulating immune complexes were present in all patients and in three skin biopsy specimens showed deposition of C3, IgG, and IgA in dermal blood vessels. Haemophilus influenzae had been isolated from the sputum of all four patients and in two patients was present at the time the cutaneous lesions appeared. It is suggested that local immune complex deposition was responsible for the skin lesions which occurred during acute exacerbations of bronchiectasis.


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