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dc.contributor.authorHayward, Elizabeth
dc.contributor.authorWhitwell, Helen
dc.contributor.authorPaul, K S
dc.contributor.authorBarnes, Diana M
dc.date.accessioned2011-03-08T16:36:53Z
dc.date.available2011-03-08T16:36:53Z
dc.date.issued1984
dc.identifier.citationSteroid receptors in human meningioma. 1984, 7 (4):351-6 Clin Neuropharmacolen
dc.identifier.issn0362-5664
dc.identifier.pmid6509446
dc.identifier.urihttp://hdl.handle.net/10541/123976
dc.description.abstractIt is well recognised that there is an increased frequency of meningioma in women compared with men and that rapid progression of the disease may occur during pregnancy. Recent studies have demonstrated steroid receptors in human meningioma. In this study we have looked for the presence of nuclear and cytoplasmic estrogen receptor (ER) and cytoplasmic progesterone receptor (PR) in 22 cases of meningioma. Radioreceptor assays using a six-point dextran-coated charcoal procedure failed to demonstrate specific ER, but 17 of 22 meningiomas did have specific PR (range 11-314 fmol/mg cytosol protein). Flat-bed isoelectric focusing in agarose gel was used to confirm the results in a few of these cases. We were not able to correlate the presence of receptor with age or sex of patient, or the site of tumour with receptor content. Of the five PR-negative tumors, one was a poor specimen when the histology was examined and two belonged to the angioblastic group (haemangiopericytic variety), a particularly aggressive tumour with a tendency to be more necrotic. The presence of PR in many of these tumours suggests a possible role for hormone therapy where total resection is not possible.
dc.language.isoenen
dc.subjectMeningeal Canceren
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChild
dc.subject.meshCytosol
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshHydrogen-Ion Concentration
dc.subject.meshIsoelectric Focusing
dc.subject.meshKinetics
dc.subject.meshMale
dc.subject.meshMeningeal Neoplasms
dc.subject.meshMeningioma
dc.subject.meshMiddle Aged
dc.subject.meshReceptors, Progesterone
dc.subject.meshReceptors, Steroid
dc.titleSteroid receptors in human meningioma.en
dc.typeArticleen
dc.identifier.journalClinical Neuropharmacologyen
html.description.abstractIt is well recognised that there is an increased frequency of meningioma in women compared with men and that rapid progression of the disease may occur during pregnancy. Recent studies have demonstrated steroid receptors in human meningioma. In this study we have looked for the presence of nuclear and cytoplasmic estrogen receptor (ER) and cytoplasmic progesterone receptor (PR) in 22 cases of meningioma. Radioreceptor assays using a six-point dextran-coated charcoal procedure failed to demonstrate specific ER, but 17 of 22 meningiomas did have specific PR (range 11-314 fmol/mg cytosol protein). Flat-bed isoelectric focusing in agarose gel was used to confirm the results in a few of these cases. We were not able to correlate the presence of receptor with age or sex of patient, or the site of tumour with receptor content. Of the five PR-negative tumors, one was a poor specimen when the histology was examined and two belonged to the angioblastic group (haemangiopericytic variety), a particularly aggressive tumour with a tendency to be more necrotic. The presence of PR in many of these tumours suggests a possible role for hormone therapy where total resection is not possible.


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