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dc.contributor.authorChapman, A J
dc.contributor.authorMacFarlane, I A
dc.contributor.authorShalet, Stephen M
dc.contributor.authorBeardwell, Colin G
dc.contributor.authorDutton, J
dc.contributor.authorSutton, M L
dc.date.accessioned2011-03-08T16:35:22Z
dc.date.available2011-03-08T16:35:22Z
dc.date.issued1984-08
dc.identifier.citationDiscordant serum alpha-subunit and FSH concentrations in a woman with a pituitary tumour. 1984, 21 (2):123-9 Clin Endocrinolen
dc.identifier.issn0300-0664
dc.identifier.pmid6205794
dc.identifier.doi10.1111/j.1365-2265.1984.tb03451.x
dc.identifier.urihttp://hdl.handle.net/10541/123972
dc.description.abstractWe have studied a women who presented at the age of 51 with a large FSH and alpha-subunit producing pituitary adenoma. Following insertion of ventriculo-peritoneal shunts and external pituitary irradiation there was no change in the elevated serum concentrations of FSH, and alpha-subunit over a four year period although she developed both ACTH and TSH deficiency. Various drugs, however, did alter the FSH and alpha-subunit concentrations and these changes suggest possible mechanisms controlling FSH secretion. Ethinyloestradiol 0.03 mg daily for three weeks suppressed serum FSH to 77% of the basal level (240 +/- 35 i.u./l to 184 +/- 20 i.u./l) but alpha-subunit rose to 130% of basal level (281 +/- 50 ng/ml to 366 +/- 40 ng/ml). On ethinyloestradiol 0.1 mg daily, FSH suppressed to 17% of basal (40 +/- 11 i.u./l) with no change in alpha-subunit concentration, while on 0.2 mg daily suppression of FSH was similar but alpha-subunit fell to 59% of basal (190 +/- 28 ng/ml). Dexamethasone, 3 mg daily for one week reduced FSH to 53% of the initial concentration and alpha-subunit to 74% while bromocriptine 7.5 mg daily for three months, reduced FSH to 39% and alpha-subunit to 66% of basal. Neither thyroxine, 0.2 mg daily for four weeks, nor an LHRH analogue, (Buserelin, Hoechst) 200 micrograms, three times daily for three months elicited any effect. Chromatography on Sephadex G100 showed that serum FSH and alpha-subunit both had Kav values somewhat lower than those of their standard counterparts (FSH, 0.20 vs 0.25; alpha-subunit 0.35 vs 0.45).(ABSTRACT TRUNCATED AT 250 WORDS)
dc.language.isoenen
dc.subjectPituitary Canceren
dc.subject.meshAdenoma, Chromophobe
dc.subject.meshBromocriptine
dc.subject.meshBuserelin
dc.subject.meshDexamethasone
dc.subject.meshEthinyl Estradiol
dc.subject.meshFemale
dc.subject.meshFollicle Stimulating Hormone
dc.subject.meshGlycoprotein Hormones, alpha Subunit
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshPeptide Fragments
dc.subject.meshPituitary Hormones, Anterior
dc.subject.meshPituitary Neoplasms
dc.subject.meshThyroxine
dc.titleDiscordant serum alpha-subunit and FSH concentrations in a woman with a pituitary tumour.en
dc.typeArticleen
dc.contributor.departmentDepartments of Endocrinology and Radiotherapy, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalClinical Endocrinologyen
html.description.abstractWe have studied a women who presented at the age of 51 with a large FSH and alpha-subunit producing pituitary adenoma. Following insertion of ventriculo-peritoneal shunts and external pituitary irradiation there was no change in the elevated serum concentrations of FSH, and alpha-subunit over a four year period although she developed both ACTH and TSH deficiency. Various drugs, however, did alter the FSH and alpha-subunit concentrations and these changes suggest possible mechanisms controlling FSH secretion. Ethinyloestradiol 0.03 mg daily for three weeks suppressed serum FSH to 77% of the basal level (240 +/- 35 i.u./l to 184 +/- 20 i.u./l) but alpha-subunit rose to 130% of basal level (281 +/- 50 ng/ml to 366 +/- 40 ng/ml). On ethinyloestradiol 0.1 mg daily, FSH suppressed to 17% of basal (40 +/- 11 i.u./l) with no change in alpha-subunit concentration, while on 0.2 mg daily suppression of FSH was similar but alpha-subunit fell to 59% of basal (190 +/- 28 ng/ml). Dexamethasone, 3 mg daily for one week reduced FSH to 53% of the initial concentration and alpha-subunit to 74% while bromocriptine 7.5 mg daily for three months, reduced FSH to 39% and alpha-subunit to 66% of basal. Neither thyroxine, 0.2 mg daily for four weeks, nor an LHRH analogue, (Buserelin, Hoechst) 200 micrograms, three times daily for three months elicited any effect. Chromatography on Sephadex G100 showed that serum FSH and alpha-subunit both had Kav values somewhat lower than those of their standard counterparts (FSH, 0.20 vs 0.25; alpha-subunit 0.35 vs 0.45).(ABSTRACT TRUNCATED AT 250 WORDS)


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