• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Hypothalamic growth hormone releasing factor deficiency following cranial irradiation.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Ahmed, S Rafeeq
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Chrisite Hospital, Manchester.
    Issue Date
    1984-11
    
    Metadata
    Show full item record
    Abstract
    The effect of synthetic human pancreatic tumour GH releasing factor (hp GRF1-44) on GH release has been studied in 10 patients with radiation-induced GH deficiency and four normal subjects. All 10 patients showed subnormal GH responses to both an ITT (median peak GH 3.2 mU/l) and to arginine stimulation (median peak GH 2.9 mU/l), although the remainder of pituitary function was intact. Following an acute intravenous bolus (100 micrograms) of hp GRF1-44, there was no GH response in two patients and a subnormal but definite GH response in a further four. The remaining four patients showed a significant GH response (median peak GH level 29 mU/l; range 22-57 mU/l) to hp GRF1-44, similar in magnitude and timing to that seen in the four normals. This strongly suggests that in these four subjects, the discrepancy in GH responses to hp GRF1-44, ITT and to arginine was a result of radiation-induced hypothalamic damage leading to a deficiency of endogenous GRF. The availability of synthetic hp GRF capable of stimulating GH secretion means that the distinction between hypothalamic and pituitary causes of GH deficiency will be of considerable therapeutic importance in the future.
    Citation
    Hypothalamic growth hormone releasing factor deficiency following cranial irradiation. 1984, 21 (5):483-8 Clin Endocrinol
    Journal
    Clinical Endocrinology
    URI
    http://hdl.handle.net/10541/123969
    DOI
    10.1111/j.1365-2265.1984.tb01385.x
    PubMed ID
    6437704
    Type
    Article
    Language
    en
    ISSN
    0300-0664
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2265.1984.tb01385.x
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Effect of growth hormone-releasing factor on growth hormone release in children with radiation-induced growth hormone deficiency.
    • Authors: Lustig RH, Schriock EA, Kaplan SL, Grumbach MM
    • Issue date: 1985 Aug
    • Cranially irradiated adult cancer survivors may have normal spontaneous GH secretion in the presence of discordant peak GH responses to stimulation tests (compensated GH deficiency).
    • Authors: Darzy KH, Thorner MO, Shalet SM
    • Issue date: 2009 Feb
    • Growth hormone response to GRF 1-44 in children following cranial irradiation for central nervous system tumors.
    • Authors: Oberfield SE, Kirkland JL, Frantz A, Allen JC, Levine LS
    • Issue date: 1987 Fall
    • Radiation and neuroregulatory control of growth hormone secretion.
    • Authors: Ogilvy-Stuart AL, Wallace WH, Shalet SM
    • Issue date: 1994 Aug
    • The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval.
    • Authors: Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM
    • Issue date: 2003 Jan
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.