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dc.contributor.authorSteward, William P
dc.contributor.authorTodd, Ian D
dc.contributor.authorHarris, Martin
dc.contributor.authorJones, J M
dc.contributor.authorBlackledge, G
dc.contributor.authorWagstaff, John
dc.contributor.authorAnderson, Heather
dc.contributor.authorWilkinson, Peter M
dc.contributor.authorCrowther, Derek
dc.date.accessioned2011-03-08T16:29:15Z
dc.date.available2011-03-08T16:29:15Z
dc.date.issued1984-07
dc.identifier.citationA multivariate analysis of factors affecting survival in patients with high-grade histology non-Hodgkin's lymphoma. 1984, 20 (7):881-9 Eur J Cancer Clin Oncolen
dc.identifier.issn0277-5379
dc.identifier.pmid6547675
dc.identifier.doi10.1016/0277-5379(84)90159-7
dc.identifier.urihttp://hdl.handle.net/10541/123968
dc.description.abstractOne hundred and eleven patients with advanced-stage, high-grade histology non-Hodgkin's lymphoma were studied over a 7-yr period and were treated with one form of chemotherapy and radiotherapy. Multivariate analyses were carried out to identify factors which could predict a favourable prognosis. A complete response, low serum LDH and absence of clinical evidence of liver involvement were associated with long-term survival. The presence of 'B' symptoms, bone marrow involvement, low serum albumin and male sex predicted a reduced chance of achieving a complete remission. For those patients who achieved a complete response, the subdivision of histologies, particularly according to the Kiel classification, was the only significant factor predictive of prolonged relapse-free and overall survival. This confirms the importance of identifying different histological subgroups of lymphoma when considering treatment planning.
dc.language.isoenen
dc.subjectCancer Stagingen
dc.subject.meshAged
dc.subject.meshAnalysis of Variance
dc.subject.meshCombined Modality Therapy
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphoma
dc.subject.meshLymphoma, Non-Hodgkin
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasm Staging
dc.subject.meshPrognosis
dc.subject.meshRisk
dc.titleA multivariate analysis of factors affecting survival in patients with high-grade histology non-Hodgkin's lymphoma.en
dc.typeArticleen
dc.contributor.departmentCRC Department Medical Oncology and Departments of Radiotherapy, Pathology, Medical Statistics and Clinical Pharmacology and Radiotherapy, Christie Hospital, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Cancer & Clinical Oncologyen
html.description.abstractOne hundred and eleven patients with advanced-stage, high-grade histology non-Hodgkin's lymphoma were studied over a 7-yr period and were treated with one form of chemotherapy and radiotherapy. Multivariate analyses were carried out to identify factors which could predict a favourable prognosis. A complete response, low serum LDH and absence of clinical evidence of liver involvement were associated with long-term survival. The presence of 'B' symptoms, bone marrow involvement, low serum albumin and male sex predicted a reduced chance of achieving a complete remission. For those patients who achieved a complete response, the subdivision of histologies, particularly according to the Kiel classification, was the only significant factor predictive of prolonged relapse-free and overall survival. This confirms the importance of identifying different histological subgroups of lymphoma when considering treatment planning.


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