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    Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group.

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    Authors
    Bramwell, Vivien H C
    Holdener, E
    Siegenthaler, P
    Ten Bokkel Huinink, W
    Bruntsch, U
    Renard, J
    Van Glabbeke, M
    Affiliation
    CRC Department Medical Oncology, Christie Hospital, Manchester, U.K.
    Issue Date
    1984-06
    
    Metadata
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    Abstract
    Forty-three patients with advanced measurable lymphoma, progressive after conventional therapy, were entered into a phase II study of m-AMSA 90-120 mg/m2 every 3 weeks. Five patients were ineligible and response could not be evaluated in four patients. For HD there were two partial responses (14%), lasting 6 and 41 weeks, in 14 evaluable patients. Among 20 evaluable patients with NHDL three (15%) achieved partial remission, but duration of response could not be evaluated. One patient with diffuse histiocytic lymphoma died of infection at 4 weeks, a second with lymphoblastic lymphoma was given high-dose steroids commencing at 6 weeks, and the third patient with nodular poorly differentiated lymphocytic lymphoma refused further treatment after one course. Leucopenia was more marked in patients with NHDL (WBC nadir X 10(9)/l, median 2.2, range 0.2-4.3) than in HD (WBC nadir X 10(9)/l, median 2.8, range 0.85-7.2), as was thrombocytopenia. There was one toxic death and one life-threatening infection, both secondary to myelosuppression. Non-haematological toxicity was mild. m-AMSA has marginal activity in previously treated lymphomas and causes considerable myelosuppression.
    Citation
    Phase II study of amsacrine in refractory lymphomas. A report of the EORTC Early Clinical Trials Group. 1984, 20 (6):753-9 Eur J Cancer Clin Oncol
    Journal
    European Journal of Cancer & Clinical Oncology
    URI
    http://hdl.handle.net/10541/123948
    DOI
    10.1016/0277-5379(84)90212-8
    PubMed ID
    6547674
    Type
    Article
    Language
    en
    ISSN
    0277-5379
    ae974a485f413a2113503eed53cd6c53
    10.1016/0277-5379(84)90212-8
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