The kinetics of hematopoietic stem cells during and after hypoxia. A model analysis.
dc.contributor.author | Loeffler, M | |
dc.contributor.author | Herkenrath, P | |
dc.contributor.author | Wichmann, H E | |
dc.contributor.author | Lord, Brian I | |
dc.contributor.author | Murphy, M J | |
dc.date.accessioned | 2011-03-08T12:20:41Z | |
dc.date.available | 2011-03-08T12:20:41Z | |
dc.date.issued | 1984-12 | |
dc.identifier.citation | The kinetics of hematopoietic stem cells during and after hypoxia. A model analysis. 1984, 49 (6):427-39 Blut | en |
dc.identifier.issn | 0006-5242 | |
dc.identifier.pmid | 6509215 | |
dc.identifier.doi | 10.1007/BF00320485 | |
dc.identifier.uri | http://hdl.handle.net/10541/123938 | |
dc.description.abstract | A previously described mathematical model of the hematopoietic stem cell system has been extended to permit a detailed understanding of the data during and after hypoxia. The model includes stem cells, erythroid and granuloid progenitors and precursors. Concerning the intramedullary feedback mechanisms two basic assumptions are made: 1) The fraction "a" of CFU-S in active cell cycle is regulated. Reduced cell densities of CFU-S, progenitors or precursors lead to an accelerated stem cell cycling. Enlarged cell densities suppress cycling. 2) The self renewal probability "p" of CFU-S is also regulated. The normal steady state is described by p = 0.5, indicating that on statistical average each dividing mother stem cell is replaced by one daughter stem cell, while the second differentiates. Diminished cell densities of CFU-S or enlarged densities of progenitors and precursors induce a more intensive self renewal (p greater than 0.5), such that the stem cell number increases. The self renewal probability declines (p less than 0.5) if too many CFU-S or too few progenitors and precursors are present. The model reproduces bone marrow data for CFU-S, BFU-E, CFU-C, CFU-E, 59 Fe-uptake and nucleated cells in hypoxia and posthypoxia. Although the ratio of differentiation into the erythroid and granuloid cell lines is kept constant in the model, a changing ratio of CFU-E and CFU-C results. The model suggests that stem cells and progenitor cells are regulated by a regulatory interference of erythropoiesis and granulopoiesis. | |
dc.language.iso | en | en |
dc.subject.mesh | Anoxia | |
dc.subject.mesh | Cell Differentiation | |
dc.subject.mesh | Erythropoiesis | |
dc.subject.mesh | Hematopoiesis | |
dc.subject.mesh | Hematopoietic Stem Cells | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Kinetics | |
dc.subject.mesh | Models, Biological | |
dc.subject.mesh | Thymidine | |
dc.title | The kinetics of hematopoietic stem cells during and after hypoxia. A model analysis. | en |
dc.type | Article | en |
dc.contributor.department | Medizinische Universitätsklinik, Joseph-Stelzmann-Stasse 9, D-5000 Köln 41, Federal Republic of Germany. | en |
dc.identifier.journal | Blut | en |
html.description.abstract | A previously described mathematical model of the hematopoietic stem cell system has been extended to permit a detailed understanding of the data during and after hypoxia. The model includes stem cells, erythroid and granuloid progenitors and precursors. Concerning the intramedullary feedback mechanisms two basic assumptions are made: 1) The fraction "a" of CFU-S in active cell cycle is regulated. Reduced cell densities of CFU-S, progenitors or precursors lead to an accelerated stem cell cycling. Enlarged cell densities suppress cycling. 2) The self renewal probability "p" of CFU-S is also regulated. The normal steady state is described by p = 0.5, indicating that on statistical average each dividing mother stem cell is replaced by one daughter stem cell, while the second differentiates. Diminished cell densities of CFU-S or enlarged densities of progenitors and precursors induce a more intensive self renewal (p greater than 0.5), such that the stem cell number increases. The self renewal probability declines (p less than 0.5) if too many CFU-S or too few progenitors and precursors are present. The model reproduces bone marrow data for CFU-S, BFU-E, CFU-C, CFU-E, 59 Fe-uptake and nucleated cells in hypoxia and posthypoxia. Although the ratio of differentiation into the erythroid and granuloid cell lines is kept constant in the model, a changing ratio of CFU-E and CFU-C results. The model suggests that stem cells and progenitor cells are regulated by a regulatory interference of erythropoiesis and granulopoiesis. |