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dc.contributor.authorHendry, Jolyon H
dc.contributor.authorClarke, D
dc.contributor.authorTesta, Nydia G
dc.contributor.authorKimber, J
dc.date.accessioned2011-03-08T12:33:39Z
dc.date.available2011-03-08T12:33:39Z
dc.date.issued1984
dc.identifier.citationLong-term injury in B-lymphocyte precursor cells in repeatedly-irradiated mice. 1984, 38 (7):343-7 Biomed Pharmacotheren
dc.identifier.issn0753-3322
dc.identifier.pmid6395914
dc.identifier.urihttp://hdl.handle.net/10541/123874
dc.description.abstractMice irradiated with 4 doses of 4.5 Gy X-rays at 3-week intervals, demonstrated long-term proliferative defects in B lymphocytes. There was a reduced mitogenic response to bacterial polysaccharide (30%), a lower concentration (35%) of B-lymphocyte colony-forming cells (BL-CFC) in agar with an increased proportion of clusters (X 2), and a reduced concentration (30%) of plaque-forming cells. Grafts of thymocytes were able to restore the levels of BL-CFC in the short term, but in the long term large grafts of femoral marrow cells were much better in restoring the numbers of BL-CFC. The reduced mitogenesis (25%) of splenocytes by concanavalin A and the diminished number of plaque-forming cells, may suggest persistent injury in T-B cell cooperation.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshB-Lymphocytes
dc.subject.meshColony-Forming Units Assay
dc.subject.meshHemolytic Plaque Technique
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMitogens
dc.subject.meshRadiation Dosage
dc.subject.meshRadiation Injuries, Experimental
dc.subject.meshSpleen
dc.subject.meshT-Lymphocytes
dc.subject.meshTime Factors
dc.subject.meshX-Rays
dc.titleLong-term injury in B-lymphocyte precursor cells in repeatedly-irradiated mice.en
dc.typeArticleen
dc.identifier.eissn1950-6007
dc.identifier.journalBiomedicine & Pharmacotherapyen
html.description.abstractMice irradiated with 4 doses of 4.5 Gy X-rays at 3-week intervals, demonstrated long-term proliferative defects in B lymphocytes. There was a reduced mitogenic response to bacterial polysaccharide (30%), a lower concentration (35%) of B-lymphocyte colony-forming cells (BL-CFC) in agar with an increased proportion of clusters (X 2), and a reduced concentration (30%) of plaque-forming cells. Grafts of thymocytes were able to restore the levels of BL-CFC in the short term, but in the long term large grafts of femoral marrow cells were much better in restoring the numbers of BL-CFC. The reduced mitogenesis (25%) of splenocytes by concanavalin A and the diminished number of plaque-forming cells, may suggest persistent injury in T-B cell cooperation.


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