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    The cellular specificity of haemopoietic stem cell proliferation regulators.

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    Authors
    Tejero, C
    Testa, Nydia G
    Lord, Brian I
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UK
    Issue Date
    1984-09
    
    Metadata
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    Abstract
    The range of specificity of the CFU-S proliferation inhibitor and stimulator which are produced endogenously in the bone marrow has been investigated by measuring their effects on the proportion of cells killed by tritiated thymidine in mixed colony- (CFC-mix), erythroid burst- (BFU-E) and granulocyte/macrophage colony- (GM-CFC) forming cells as well as spleen colony forming units (CFU-S). Both CFU-S and CFC-mix were triggered by the stimulator into DNA-synthesis but BFU-E and GM-CFC were unaffected. The range of activity of the inhibitor was confined solely to the CFU-S population. This defined the specificity of both inhibitor and stimulator for the multipotent cells. The differential sensitivity of CFU-S and CFC-mix to the inhibitor and the lack of it for the stimulator suggested (a) that the CFC-mix is a relatively mature subpopulation of the CFU-S compartment and (b) that the relative sensitivity of a CFU-S to these factors changes as it matures from the early stem cell stage (Inhibitor-sensitive) to the more mature stages (Stimulator-sensitive) before becoming committed to a specific line of differentiation. The specificity of the inhibitor for haemopoietic stem cells suggests its potential value during chemotherapeutic procedures.
    Citation
    The cellular specificity of haemopoietic stem cell proliferation regulators. 1984, 50 (3):335-41 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/123873
    PubMed ID
    6331841
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    EISSN
    1532-1827
    Collections
    All Paterson Institute for Cancer Research

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