Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status.
dc.contributor.author | Moore, James V | |
dc.contributor.author | Hopkins, H A | |
dc.contributor.author | Looney, W B | |
dc.date.accessioned | 2011-03-07T23:50:31Z | |
dc.date.available | 2011-03-07T23:50:31Z | |
dc.date.issued | 1984 | |
dc.identifier.citation | Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. 1984, 23 (3):213-22 Radiat Environ Biophys | en |
dc.identifier.issn | 0301-634X | |
dc.identifier.pmid | 6473705 | |
dc.identifier.doi | 10.1007/BF01213223 | |
dc.identifier.uri | http://hdl.handle.net/10541/123805 | |
dc.description.abstract | Tumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance. | |
dc.language.iso | en | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Dose-Response Relationship, Radiation | |
dc.subject.mesh | Female | |
dc.subject.mesh | Liver Neoplasms, Experimental | |
dc.subject.mesh | Neoplasm Transplantation | |
dc.subject.mesh | Oxygen | |
dc.subject.mesh | Radiation Tolerance | |
dc.subject.mesh | Rats | |
dc.subject.mesh | Rats, Inbred ACI | |
dc.title | Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. | en |
dc.type | Article | en |
dc.identifier.eissn | 1432-2099 | |
dc.contributor.department | Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UK | en |
dc.identifier.journal | Radiation and Environmental Biophysics | en |
html.description.abstract | Tumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance. |