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dc.contributor.authorMoore, James Ven
dc.contributor.authorHopkins, H Aen
dc.contributor.authorLooney, W Ben
dc.date.accessioned2011-03-07T23:50:31Z
dc.date.available2011-03-07T23:50:31Z
dc.date.issued1984
dc.identifier.citationTumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. 1984, 23 (3):213-22 Radiat Environ Biophysen
dc.identifier.issn0301-634X
dc.identifier.pmid6473705
dc.identifier.doi10.1007/BF01213223
dc.identifier.urihttp://hdl.handle.net/10541/123805
dc.description.abstractTumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshDose-Response Relationship, Radiation
dc.subject.meshFemale
dc.subject.meshLiver Neoplasms, Experimental
dc.subject.meshNeoplasm Transplantation
dc.subject.meshOxygen
dc.subject.meshRadiation Tolerance
dc.subject.meshRats
dc.subject.meshRats, Inbred ACI
dc.titleTumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status.en
dc.typeArticleen
dc.identifier.eissn1432-2099
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UKen
dc.identifier.journalRadiation and Environmental Biophysicsen
html.description.abstractTumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance.


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