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    Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status.

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    Authors
    Moore, James V
    Hopkins, H A
    Looney, W B
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UK
    Issue Date
    1984
    
    Metadata
    Show full item record
    Abstract
    Tumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance.
    Citation
    Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. 1984, 23 (3):213-22 Radiat Environ Biophys
    Journal
    Radiation and Environmental Biophysics
    URI
    http://hdl.handle.net/10541/123805
    DOI
    10.1007/BF01213223
    PubMed ID
    6473705
    Type
    Article
    Language
    en
    ISSN
    0301-634X
    EISSN
    1432-2099
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF01213223
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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