Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status.
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Wilmslow Road, Withington, Manchester M20 9BX, UKIssue Date
1984
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Tumour cords have been examined quantitatively in two rat hepatomas, 3924A and H-4-II-E, that differ in their radiobiological oxygenation status (oxygen enhancement ratio for growth delay [tumour clamped: tumor 'in air'] was 1.35 for 3924A and only 1.08 for H-4-II-E). The average thickness of tumour cords in 3924A was 118 microns and only 69 microns in H-4-II-E. The migration rates across the cords of the two tumours were approximately the same (1.7 and 1.4 micron X h-1) but for any given distance from the subtending blood vessel, the proportion of histologically-dead cells within the cord was always higher for H-4-II-E. Volume for volume, H-4-II-E contained four times as much vascular space as 3924A but it is suggested that the poor quality of this vasculature in H-4-II-E contributed to its relative radioresistance.Citation
Tumour-cord parameters in two rat hepatomas that differ in their radiobiological oxygenation status. 1984, 23 (3):213-22 Radiat Environ BiophysJournal
Radiation and Environmental BiophysicsDOI
10.1007/BF01213223PubMed ID
6473705Type
ArticleLanguage
enISSN
0301-634XEISSN
1432-2099ae974a485f413a2113503eed53cd6c53
10.1007/BF01213223
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