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dc.contributor.authorPoppitt, David G
dc.contributor.authorMcGown, Alan T
dc.contributor.authorFox, Brian W
dc.date.accessioned2011-03-06T22:35:59Z
dc.date.available2011-03-06T22:35:59Z
dc.date.issued1984
dc.identifier.citationCollateral sensitivity of a methotrexate-resistant L1210 cell line to the vinca alkaloids. 1984, 13 (1):43-6 Cancer Chemother. Pharmacol.en
dc.identifier.issn0344-5704
dc.identifier.pmid6733841
dc.identifier.doi10.1007/BF00401446
dc.identifier.urihttp://hdl.handle.net/10541/123695
dc.description.abstractL1210 mouse leukaemia cell lines showing a 20,000-fold differential sensitivity to methotrexate have been shown to exhibit some collateral sensitivity to at least two of the vinca alkaloids, vinblastine and vindesine. Vinblastine is the more cytotoxic for both cell lines. The extent of the collateral sensitivity decreases in the order vindesine greater than vinblastine greater than vincristine. Total cellular uptake studies with radiolabelled methotrexate showed only a two- to three-fold greater incorporation in the sensitive line. On the other hand, a two-fold greater incorporation of labelled vincristine occurred in the resistant line. No significant difference in the uptake occurred following labelled vinblastine treatment by the two cell lines. It is unlikely that differences in uptake account for the altered drug responses observed in the two cell lines.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Line
dc.subject.meshCell Survival
dc.subject.meshDrug Resistance
dc.subject.meshGene Amplification
dc.subject.meshLeukemia L1210
dc.subject.meshMethotrexate
dc.subject.meshMice
dc.subject.meshVinblastine
dc.subject.meshVinca Alkaloids
dc.subject.meshVincristine
dc.subject.meshVindesine
dc.titleCollateral sensitivity of a methotrexate-resistant L1210 cell line to the vinca alkaloids.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UKen
dc.identifier.journalCancer Chemotherapy and Pharmacologyen
html.description.abstractL1210 mouse leukaemia cell lines showing a 20,000-fold differential sensitivity to methotrexate have been shown to exhibit some collateral sensitivity to at least two of the vinca alkaloids, vinblastine and vindesine. Vinblastine is the more cytotoxic for both cell lines. The extent of the collateral sensitivity decreases in the order vindesine greater than vinblastine greater than vincristine. Total cellular uptake studies with radiolabelled methotrexate showed only a two- to three-fold greater incorporation in the sensitive line. On the other hand, a two-fold greater incorporation of labelled vincristine occurred in the resistant line. No significant difference in the uptake occurred following labelled vinblastine treatment by the two cell lines. It is unlikely that differences in uptake account for the altered drug responses observed in the two cell lines.


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