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    Collateral sensitivity of a methotrexate-resistant L1210 cell line to the vinca alkaloids.

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    Authors
    Poppitt, David G
    McGown, Alan T
    Fox, Brian W
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, UK
    Issue Date
    1984
    
    Metadata
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    Abstract
    L1210 mouse leukaemia cell lines showing a 20,000-fold differential sensitivity to methotrexate have been shown to exhibit some collateral sensitivity to at least two of the vinca alkaloids, vinblastine and vindesine. Vinblastine is the more cytotoxic for both cell lines. The extent of the collateral sensitivity decreases in the order vindesine greater than vinblastine greater than vincristine. Total cellular uptake studies with radiolabelled methotrexate showed only a two- to three-fold greater incorporation in the sensitive line. On the other hand, a two-fold greater incorporation of labelled vincristine occurred in the resistant line. No significant difference in the uptake occurred following labelled vinblastine treatment by the two cell lines. It is unlikely that differences in uptake account for the altered drug responses observed in the two cell lines.
    Citation
    Collateral sensitivity of a methotrexate-resistant L1210 cell line to the vinca alkaloids. 1984, 13 (1):43-6 Cancer Chemother. Pharmacol.
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/123695
    DOI
    10.1007/BF00401446
    PubMed ID
    6733841
    Type
    Article
    Language
    en
    ISSN
    0344-5704
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00401446
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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