The recruitability and cell-cycle state of intestinal stem cells.
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, United KingdomIssue Date
1984-03
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Evidence is presented which suggests that the crypts of the small intestine contain at least two discrete but interdependent classes of stem cells, some with discrete cell kinetic properties and some with discrete radiation responses or radiosensitivities. Very low doses of X rays or gamma rays, or neutrons, kill a few cells in the stem cell regions of the crypt in a sensitive dose-dependent manner. Similar doses generate several different cell kinetic responses within either the clonogenic fraction or the cells at the stem cell position within the crypt. The cell kinetic responses range from apparent recruitment of G0 clonogenic cells into cycle, to a marked shortening of the average cell cycle of the cells at the stem cell position. It is suggested that the cell kinetic changes may be the consequence of the cell destruction.Citation
The recruitability and cell-cycle state of intestinal stem cells. 1984, 2 (2):126-40 Int. J. Cell CloningJournal
International Journal of Cell CloningDOI
10.1002/stem.5530020206PubMed ID
6707492Type
ArticleLanguage
enISSN
0737-1454ae974a485f413a2113503eed53cd6c53
10.1002/stem.5530020206
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