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dc.contributor.authorKimber, I
dc.contributor.authorBakács, T
dc.contributor.authorRoberts, K
dc.contributor.authorMoore, Michael
dc.date.accessioned2011-03-06T22:21:33Z
dc.date.available2011-03-06T22:21:33Z
dc.date.issued1984-10
dc.identifier.citationInfluence of lectin-free interleukin-2 on natural and antibody-dependent cellular cytotoxicity. 1984, 15 (2):77-84 J Clin Lab Immunolen
dc.identifier.issn0141-2760
dc.identifier.pmid6440995
dc.identifier.urihttp://hdl.handle.net/10541/123685
dc.description.abstractSupernatants derived from MLA-144, a gibbon T cell line that constitutively releases interleukin-2 (IL-2) and which lack detectable interferon (IFN) had the capacity to enhance the natural killer (NK) cells function of human peripheral blood lymphocytes. Percoll fractionation revealed that like IFN-inducible cytotoxic cells lymphocytes responding to MLA-144 supernatants cofractionate with native NK cells. Exposure to MLA-144 conditioned medium also potentiated the cytotoxic capacity of extravascular effector cells which are either unresponsive or weakly responsive to interferon-alpha (IFN-alpha). Moreover lymphocyte (K cell)-mediated antibody-dependent cellular cytotoxicity (ADCC) which is unresponsive to IFN-alpha was in most cases subject to a modest potentiation following treatment with MLA-144 supernatants. These data confirm previous reports that IL-2 can regulate peripheral blood NK cell function and also demonstrate that this lymphokine can also influence those natural cytotoxic mechanisms which are unresponsive to IFN-alpha.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshAntibody-Dependent Cell Cytotoxicity
dc.subject.meshCell Line
dc.subject.meshCytotoxicity, Immunologic
dc.subject.meshEnterotoxins
dc.subject.meshHumans
dc.subject.meshHylobates
dc.subject.meshInterferon Type I
dc.subject.meshInterferon-gamma
dc.subject.meshInterleukin-2
dc.subject.meshKiller Cells, Natural
dc.subject.meshLectins
dc.titleInfluence of lectin-free interleukin-2 on natural and antibody-dependent cellular cytotoxicity.en
dc.typeArticleen
dc.identifier.journalJournal of Clinical & Laboratory Immunologyen
html.description.abstractSupernatants derived from MLA-144, a gibbon T cell line that constitutively releases interleukin-2 (IL-2) and which lack detectable interferon (IFN) had the capacity to enhance the natural killer (NK) cells function of human peripheral blood lymphocytes. Percoll fractionation revealed that like IFN-inducible cytotoxic cells lymphocytes responding to MLA-144 supernatants cofractionate with native NK cells. Exposure to MLA-144 conditioned medium also potentiated the cytotoxic capacity of extravascular effector cells which are either unresponsive or weakly responsive to interferon-alpha (IFN-alpha). Moreover lymphocyte (K cell)-mediated antibody-dependent cellular cytotoxicity (ADCC) which is unresponsive to IFN-alpha was in most cases subject to a modest potentiation following treatment with MLA-144 supernatants. These data confirm previous reports that IL-2 can regulate peripheral blood NK cell function and also demonstrate that this lymphokine can also influence those natural cytotoxic mechanisms which are unresponsive to IFN-alpha.


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