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    Effect of src infection on long-term marrow cultures: increased self-renewal of hemopoietic progenitor cells without leukemia.

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    Authors
    Boettiger, David
    Anderson, Steven
    Dexter, T Michael
    Affiliation
    Department of Microbiology University of Pennsylvania Philadelphia, Pennsylvania 19104
    Issue Date
    1984-03
    
    Metadata
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    Abstract
    Long-term marrow cultures prepared from mice have been infected with a molecular recombinant of Rous sarcoma virus and murine amphitropic leukemia virus. This resulted in introduction of the src gene into the cultured cells and expression of its protein kinase function. The infected cultures displayed an altered balance in the accumulation of cells in different compartments of granulocyte differentiation. There was a dramatic increase in the stem cell (CFU-S) compartment and the committed progenitor cell (GM-CFC) compartment and a decrease in mature granulocytes. The altered balance appears to be caused by intrinsic alterations in the CFU-S and GM-CFC themselves, which increase their "self-renewal" capacity at the expense of cell differentiation. Remarkably, unlike its effects in other systems, src did not produce a neoplastic transformation of the hemopoietic cells.
    Citation
    Effect of src infection on long-term marrow cultures: increased self-renewal of hemopoietic progenitor cells without leukemia. 1984, 36 (3):763-73 Cell
    Journal
    Cell
    URI
    http://hdl.handle.net/10541/123671
    DOI
    10.1016/0092-8674(84)90356-8
    PubMed ID
    6321038
    Type
    Article
    Language
    en
    ISSN
    0092-8674
    ae974a485f413a2113503eed53cd6c53
    10.1016/0092-8674(84)90356-8
    Scopus Count
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    All Paterson Institute for Cancer Research

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