Randomized phase II trial of carminomycin versus 4'-epidoxorubicin in advanced breast cancer.
Authors
Rozencweig, MTen Bokkel Huinink, W
Cavalli, F
Bruntsch, U
Dombernowsky, P
Høst, H
Bramwell, Vivien H C
Renard, G
Van Glabbeke, M
Decoster, G
Affiliation
Institut Jules Bordet, Brussels, BelgiumIssue Date
1984-04
Metadata
Show full item recordAbstract
Sixty-three evaluable patients with advanced breast cancer were randomly allocated to receive three-week intravenous courses of carminomycin (18 mg/m2) or 4'-epidoxorubicin (90 mg/m2). The former yielded one (3%) partial response for nine weeks among 29 patients whereas, in the other arm, nine (27%) of 34 patients achieved partial response for a median of 28 weeks (range, nine to 36 weeks; p less than 0.02). The major toxic effect of these anthracyclines was leukopenia with median white blood cell nadirs of 1,600/microL (range, 300-4,000/microL) versus 1,800/microL (range, 500-4,300/microL), respectively. Acute nonhematologic toxic effects were qualitatively similar but carminomycin produced significantly less gastrointestinal intolerance and alopecia. Patients whose disease failed to respond to first-line anthracycline received doxorubicin (60 mg/m2) every three weeks. Four partial responses were obtained among 19 patients previously treated with carminomycin. Following 4'-epidoxorubicin therapy, one of 12 evaluable patients also attained partial response. Survival curves were not affected by the initial treatment option. Carminomycin has marginal activity against breast cancer whereas 4'-epidoxorubicin deserves further evaluation of its therapeutic index relative to doxorubicin. The design used in this trial appears attractive for prompt phase II evaluation of anthracycline analogs.Citation
Randomized phase II trial of carminomycin versus 4'-epidoxorubicin in advanced breast cancer. 1984, 2 (4):275-81 J Clin OncolJournal
Journal of Clinical OncologyPubMed ID
6584561Type
ArticleLanguage
enISSN
0732-183XCollections
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