• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Evans, D Gareth R
    Lalloo, Fiona
    Cramer, A
    Jones, E
    Knox, F
    Amir, E
    Howell, Anthony
    Affiliation
    University of Manchester, Central Manchester Foundation Hospital NHS Trust, St Mary's Hospital, Manchester, UK. Gareth.evans@cmft.nhs.uk
    Issue Date
    2009-12
    
    Metadata
    Show full item record
    Abstract
    Selection for genetic testing of BRCA1/BRCA2 is an important area of healthcare. Although testing costs for mutational analysis are falling, costs in North America remain in excess of US$3000 (UK price can be 690 pounds). Guidelines in most countries use a 10-20% threshold of detecting a mutation in BRCA1/2 combined within a family before mutational analysis is considered. A number of computer-based models have been developed. However, use of these models can be time consuming and difficult. The Manchester scoring system was developed in 2003 to simplify the selection process without losing accuracy.
    Citation
    Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing. 2009, 46 (12):811-7 J Med Genet
    Journal
    Journal of Medical Genetics
    URI
    http://hdl.handle.net/10541/121325
    DOI
    10.1136/jmg.2009.067850
    PubMed ID
    19542080
    Type
    Article
    Language
    en
    ISSN
    1468-6244
    ae974a485f413a2113503eed53cd6c53
    10.1136/jmg.2009.067850
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Development of a scoring system to screen for BRCA1/2 mutations.
    • Authors: Evans GR, Lalloo F
    • Issue date: 2010
    • Optimal selection of individuals for BRCA mutation testing: a comparison of available methods.
    • Authors: James PA, Doherty R, Harris M, Mukesh BN, Milner A, Young MA, Scott C
    • Issue date: 2006 Feb 1
    • Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals.
    • Authors: Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, Doody MM, Tucker MA, Greene MH, Zhang J, Struewing JP
    • Issue date: 2003 Aug
    • Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers.
    • Authors: van der Groep P, van Diest PJ, Menko FH, Bart J, de Vries EG, van der Wall E
    • Issue date: 2009 Oct
    • Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil.
    • Authors: Gomes MC, Costa MM, Borojevic R, Monteiro AN, Vieira R, Koifman S, Koifman RJ, Li S, Royer R, Zhang S, Narod SA
    • Issue date: 2007 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.