Study of parathyroid transcription factor Gcm2 expression in parathyroid lesions.
Authors
Nonaka, DaisukeAffiliation
Department of Histopathology, Christie NHS Foundation Trust, Manchester, UK. Daisuke.Nonaka@christie.nhs.ukIssue Date
2011-01
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Glial cells missing 2 (Gcm2) is a master regulatory gene of parathyroid gland development, and it is exclusively expressed in the parathyroid gland. Diagnostic application of anti-Gcm2 antibody has not been reported yet. In this study, a total of 58 cases of parathyroid lesions including 40 adenomas, 2 atypical adenomas, 2 carcinomas, 9 hyperplastic lesions, 4 parathyroid cysts, and 1 case of recurrent hyperplasia of an autograft gland were stained with anti-Gcm2 antibody. Anti-Gcm2 was also applied to a variety of endocrine tumors, including thyroid tumors and nonendocrine tumors, and normal tissues from a variety of organs, including the parathyroid and thyroid glands. Gcm2 nuclear expression was seen in all the normal parathyroid glands, and cystic, hyperplastic, and neoplastic parathyroid lesions in a diffuse manner, whereas no Gcm2 expression was seen in any other normal tissues and tumors, including those of the thymus and thyroid gland. Anti-Gcm2 antibody is a highly sensitive and specific marker for parathyroid lesions. Although the immunohistochemistry stain for parathyroid hormone is a useful marker, its reaction tends to be variable in extent and intensity in parathyroid neoplasia, and it is often negative in parathyroid cysts, and Gcm2 would serve as a useful adjunct marker.Citation
Study of parathyroid transcription factor Gcm2 expression in parathyroid lesions. 2011, 35 (1):145-51 Am J Surg PatholJournal
The American Journal of Surgical PathologyDOI
10.1097/PAS.0b013e31820371e4PubMed ID
21164298Type
ArticleLanguage
enISSN
1532-0979ae974a485f413a2113503eed53cd6c53
10.1097/PAS.0b013e31820371e4