• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Treatment of limited small cell lung cancer: an old or new challenge?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Blackhall, Fiona H
    Faivre-Finn, Corinne
    Affiliation
    Department of Medical Oncology, UK bDepartment of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
    Issue Date
    2010-11-22
    
    Metadata
    Show full item record
    Abstract
    PURPOSE OF REVIEW: This review highlights how progress has been made in treating limited small cell lung cancer and outlines current challenges to overcome for improved cure rates. RECENT FINDINGS: There is a rationale for the tumour, node, metastasis staging system to replace the current convention of limited versus extensive stage. Positron emission tomography may aid in staging but prospective validation in larger series of patients is needed. Cisplatin and etoposide chemotherapy has yet to be superseded by either newer cytotoxic drugs or targeted agents. More progress has been made for radiotherapy but questions of optimal dose, schedule, timing and treatment volume remain unanswered. SUMMARY: Concurrent chemoradiotherapy is associated with a one in four chance of cure. Two ongoing phase III trials have been designed to address the optimal radiotherapy regimen to combine with cisplatin and etoposide. Close collaboration between radiation and medical oncologists is needed to make further progress and to improve patient access to curative intent concurrent chemoradiotherapy regimens.
    Citation
    Treatment of limited small cell lung cancer: an old or new challenge? 2010: Curr Opin Oncol
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/120153
    DOI
    10.1097/CCO.0b013e328341ee4d
    PubMed ID
    21107256
    Type
    Article
    Language
    en
    ISSN
    1531-703X
    ae974a485f413a2113503eed53cd6c53
    10.1097/CCO.0b013e328341ee4d
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • [The role of surgical resection in treating small cell lung cancer].
    • Authors: Ye B, Zhao SH, Liu XY
    • Issue date: 2007 Jul
    • Current role of surgery in small cell lung carcinoma.
    • Authors: Koletsis EN, Prokakis C, Karanikolas M, Apostolakis E, Dougenis D
    • Issue date: 2009 Jul 9
    • Surgery for limited stage small cell lung cancer: time to fish or cut bait.
    • Authors: Shepherd FA
    • Issue date: 2010 Feb
    • Treatment of limited disease small cell lung cancer.
    • Authors: De Ruysscher D
    • Issue date: 2009 Sep
    • Treatment of small-cell lung cancer in elderly patients.
    • Authors: Pallis AG, Shepherd FA, Lacombe D, Gridelli C
    • Issue date: 2010 Mar 1
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.