The role of allogeneic SCT in primary myelofibrosis: a British Society for Blood and Marrow Transplantation study.
Authors
Stewart, WPearce, R
Kirkland, K
Bloor, Adrian
Thomson, K
Apperley, J
McQuaker, G
Marks, D
Craddock, C
McCann, S
Russell, N
Cook, G
Kottaridis, P
Affiliation
Cancer Science Institute, National University of Singapore, Singapore.Issue Date
2010-11
Metadata
Show full item recordAbstract
Fifty-one patients with primary myelofibrosis (PMF) received allogeneic haematopoietic stem cell transplants from related (n=33) or unrelated (n=18) donors. Twenty-seven patients, 19-54 years old, were prepared with myeloablative regimens including CY plus BU (n=4) or TBI (n=23). Twenty-four patients, 40-64 years old, received reduced-intensity conditioning (RIC) regimens. All RIC regimens contained fludarabine, combined with melphalan (n=19) or BU (n=5), and alemtuzumab or anti-thymocyte globulin (ATG) in the majority (n=19). Four patients (17%) in the RIC group had primary graft failure. Previous splenectomy reduced time to engraftment in the RIC group (13 versus 20 days; P=0.008). For MA and RIC groups, respectively, at 3 years, overall survival rates were 44 and 31% (P=0.67), progression-free survival 44 and 24% (P=0.87), and actuarial relapse rates 15 and 46% (P=0.06). Non-relapse mortality at 3 years was 41% for the myeloablative and 32% for the RIC group. Acute GVHD occurred in 29 and 38% of patients in the myeloablative and RIC groups, respectively. Extensive chronic GVHD developed in 30 and 35% of evaluable patients, respectively.Citation
The role of allogeneic SCT in primary myelofibrosis: a British Society for Blood and Marrow Transplantation study. 2010, 45 (11):1587-93 Bone Marrow TransplantJournal
Bone Marrow TransplantationDOI
10.1038/bmt.2010.14PubMed ID
20154739Type
ArticleLanguage
enISSN
1476-5365ae974a485f413a2113503eed53cd6c53
10.1038/bmt.2010.14