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    p27(Kip1) is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients.

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    Authors
    Stendahl, M
    Nilsson, Sofie
    Wigerup, C
    Jirström, K
    Jönsson, P
    Stål, O
    Landberg, Göran
    Affiliation
    Center for Molecular Pathology, Lund University, Malmö University Hospital, Malmö, Sweden.
    Issue Date
    2010-03-03
    
    Metadata
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    Abstract
    The cell cycle regulating protein p27(Kip1) (p27) has dual roles by acting as both a cdk-inhibitor and as an assembly factor for different cdk-complexes. Loss of p27 has been linked to malignant features in tumours, however the exact role of p27 deregulation in breast cancer regarding prognostic and treatment predictive information has not been fully clarified. We have evaluated p27 expression in 328 primary, stage II breast cancers from premenopausal patients who had been randomised to either tamoxifen treatment or no adjuvant treatment after surgery. p27 was associated with the oestrogen receptor (ER) and cyclin D1, and p27 downregulation was associated with high proliferation. There was no association between recurrence-free-survival (RFS) and p27 (HR=0.800, 95%CI 0.523-1.222, p=0.300), indicating that p27 is not a prognostic marker. The predictive value of p27 was analysed by comparing RFS in tamoxifen treated and untreated patients in subgroups of low and high p27 expression (HR=0.747, 95%CI 0.335-1.664, p=0.474 and HR=0.401, 95%CI 0.240-0.670, p<0.001, respectively). Only patients with p27 high tumours benefited from tamoxifen (multivariate interaction analysis p=0.034). Our study suggests that p27 downregulation is associated with tamoxifen resistance in premenopausal breast cancer but is not linked to impaired prognosis. (c) 2010 UICC.
    Citation
    p27(Kip1) is a predictive factor for tamoxifen treatment response but not a prognostic marker in premenopausal breast cancer patients. 2010: Int J Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/120109
    DOI
    10.1002/ijc.25297
    PubMed ID
    20201092
    Type
    Article
    Language
    en
    ISSN
    1097-0215
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.25297
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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