AffiliationSignalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK.
MetadataShow full item record
AbstractProtein kinases orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of numerous intracellular signaling pathways is highlighted by the number of kinases encoded by the human genome (539) and the plethora of phosphorylation sites identified in phosphoproteomic studies. Perturbation of these signaling networks by mutations or abnormal protein expression underlies the cause of many diseases including cancer. Recent RNAi screens and cancer genomic sequencing studies have revealed that many more kinases than anticipated contribute to tumorigenesis and are potential targets for inhibitor drug development intervention. This review will highlight recent insights into known pathways essential for tumorigenesis and discuss exciting new pathways for therapeutic intervention.
CitationProtein kinase signaling networks in cancer. 2010: Curr Opin Genet Dev
JournalCurrent Opinion in Genetics & Development
- Challenges and opportunities in defining the essential cancer kinome.
- Authors: Manning BD
- Issue date: 2009 Mar 24
- Protein kinases curb cell death.
- Authors: Filhol O, Cochet C
- Issue date: 2011 May 10
- Phosphoproteomics for oncology discovery and treatment.
- Authors: Stern DF
- Issue date: 2005 Aug
- Protein kinases that phosphorylate splicing factors: Roles in cancer development, progression and possible therapeutic options.
- Authors: Czubaty A, Piekiełko-Witkowska A
- Issue date: 2017 Oct
- Epigenetic regulation of RTK signaling.
- Authors: Spangle JM, Roberts TM
- Issue date: 2017 Aug