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    Protein kinase signaling networks in cancer.

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    Authors
    Brognard, J
    Hunter, Tony
    Affiliation
    Signalling Networks in Cancer Group, Cancer Research UK, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK.
    Issue Date
    2010-11-29
    
    Metadata
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    Abstract
    Protein kinases orchestrate the activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of numerous intracellular signaling pathways is highlighted by the number of kinases encoded by the human genome (539) and the plethora of phosphorylation sites identified in phosphoproteomic studies. Perturbation of these signaling networks by mutations or abnormal protein expression underlies the cause of many diseases including cancer. Recent RNAi screens and cancer genomic sequencing studies have revealed that many more kinases than anticipated contribute to tumorigenesis and are potential targets for inhibitor drug development intervention. This review will highlight recent insights into known pathways essential for tumorigenesis and discuss exciting new pathways for therapeutic intervention.
    Citation
    Protein kinase signaling networks in cancer. 2010: Curr Opin Genet Dev
    Journal
    Current Opinion in Genetics & Development
    URI
    http://hdl.handle.net/10541/120106
    DOI
    10.1016/j.gde.2010.10.012
    PubMed ID
    21123047
    Type
    Article
    Language
    en
    ISSN
    1879-0380
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.gde.2010.10.012
    Scopus Count
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    All Paterson Institute for Cancer Research

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