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dc.contributor.authorHarrison, Hannahen
dc.contributor.authorFarnie, Gillianen
dc.contributor.authorBrennan, Ken
dc.contributor.authorClarke, Robert Ben
dc.date.accessioned2011-01-20T12:36:10Z
dc.date.available2011-01-20T12:36:10Z
dc.date.issued2010-11-15
dc.identifier.citationBreast cancer stem cells: something out of notching? 2010, 70 (22):8973-6 Cancer Resen
dc.identifier.issn1538-7445
dc.identifier.pmid21045140
dc.identifier.doi10.1158/0008-5472.CAN-10-1559
dc.identifier.urihttp://hdl.handle.net/10541/120018
dc.description.abstractWe and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.
dc.language.isoenen
dc.subjectBreast Cancer
dc.titleBreast cancer stem cells: something out of notching?en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.en
dc.identifier.journalCancer Researchen
html.description.abstractWe and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.


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