Affiliation
Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.Issue Date
2010-11-15
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Show full item recordAbstract
We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.Citation
Breast cancer stem cells: something out of notching? 2010, 70 (22):8973-6 Cancer ResJournal
Cancer ResearchDOI
10.1158/0008-5472.CAN-10-1559PubMed ID
21045140Type
ArticleLanguage
enISSN
1538-7445ae974a485f413a2113503eed53cd6c53
10.1158/0008-5472.CAN-10-1559
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