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    Breast cancer stem cells: something out of notching?

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    Authors
    Harrison, Hannah
    Farnie, Gillian
    Brennan, K
    Clarke, Robert B
    Affiliation
    Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.
    Issue Date
    2010-11-15
    
    Metadata
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    Abstract
    We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.
    Citation
    Breast cancer stem cells: something out of notching? 2010, 70 (22):8973-6 Cancer Res
    Journal
    Cancer Research
    URI
    http://hdl.handle.net/10541/120018
    DOI
    10.1158/0008-5472.CAN-10-1559
    PubMed ID
    21045140
    Type
    Article
    Language
    en
    ISSN
    1538-7445
    ae974a485f413a2113503eed53cd6c53
    10.1158/0008-5472.CAN-10-1559
    Scopus Count
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    All Paterson Institute for Cancer Research

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