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    Identification and cloning in yeast artificial chromosomes of a region of elevated loss of heterozygosity on chromosome 1p31.1 in human breast cancer.

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    Authors
    Hoggard, Nigel
    Hey, Yvonne
    Brintnell, Bill
    James, Louise A
    Jones, David
    Mitchell, Erika L D
    Weissenbach, J
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom.
    Issue Date
    1995-11-20
    
    Metadata
    Show full item record
    Abstract
    We have mapped a region of high loss of heterozygosity in breast cancer to a 2-cM interval between the loci D1S430 and D1S465 on chromosome 1p31.1. This region shows allelic imbalance in around 60% of breast tumors. As part of a strategy to clone the target gene(s) within this interval, we have generated a yeast artificial chromosome contig spanning over 7 Mb. YACs from the CEPH and Zeneca (formerly ICI) libraries have been obtained by screening with PCR-based STSs from the region for both previously identified loci and newly isolated STSs. The YACs have been assembled into a contig by a combination of approaches, including analysis of their STS content, generation of new STSs from the ends of key YACs, and long-range restriction mapping. These YAC clones provide the basis for complete characterization of the region of high loss in breast cancer and for the ultimate identification of the target gene(s).
    Citation
    Identification and cloning in yeast artificial chromosomes of a region of elevated loss of heterozygosity on chromosome 1p31.1 in human breast cancer. 1995, 30 (2):233-43 Genomics
    Journal
    Genomics
    URI
    http://hdl.handle.net/10541/117668
    DOI
    10.1006/geno.1995.9882
    PubMed ID
    8586422
    Type
    Article
    Language
    en
    ISSN
    0888-7543
    ae974a485f413a2113503eed53cd6c53
    10.1006/geno.1995.9882
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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