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dc.contributor.authorMitchell, Erika L D
dc.date.accessioned2010-12-10T12:54:41Z
dc.date.available2010-12-10T12:54:41Z
dc.date.issued1990-07-01
dc.identifier.citationA cytogenetic study of male breast cancer. 1990, 47 (1):107-12 Cancer Genet Cytogeneten
dc.identifier.issn0165-4608
dc.identifier.pmid2162731
dc.identifier.urihttp://hdl.handle.net/10541/117667
dc.description.abstractIn a direct preparation from a male breast carcinoma two populations of cells were present, one hypodiploid (range 25-34) and the other hypertriploid (range 56-84). Twenty-two marker chromosomes were recognized. One of these, dic(5:11)(p14:q23) was present in one or two copies in every cell and has not been reported in any other case of breast cancer. There was a consistent monosomy of chromosome 7 and, in the hypertriploid cells, a gain of one to three copies of chromosome 3. The breakpoint 11q23 is a rare, folate-sensitive fragile site but was not expressed in peripheral blood cell lymphocytes from the patient.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAged
dc.subject.meshBreast Neoplasms
dc.subject.meshCarcinoma, Intraductal, Noninfiltrating
dc.subject.meshChromosome Aberrations
dc.subject.meshChromosome Banding
dc.subject.meshGenetic Markers
dc.subject.meshHumans
dc.subject.meshKaryotyping
dc.subject.meshMale
dc.titleA cytogenetic study of male breast cancer.en
dc.typeArticleen
dc.contributor.departmentCancer Genetics Department, Paterson Institute for Cancer Research, Christie Hospital, Manchester, England.en
dc.identifier.journalCancer Genetics and Cytogeneticsen
dc.identifier.pmcid10.1016/0165-4608(90)90270-K
html.description.abstractIn a direct preparation from a male breast carcinoma two populations of cells were present, one hypodiploid (range 25-34) and the other hypertriploid (range 56-84). Twenty-two marker chromosomes were recognized. One of these, dic(5:11)(p14:q23) was present in one or two copies in every cell and has not been reported in any other case of breast cancer. There was a consistent monosomy of chromosome 7 and, in the hypertriploid cells, a gain of one to three copies of chromosome 3. The breakpoint 11q23 is a rare, folate-sensitive fragile site but was not expressed in peripheral blood cell lymphocytes from the patient.


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