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Effect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells.

dc.contributor.authorWright, Eric G
dc.contributor.authorLorimore, S A
dc.contributor.authorLord, Brian I
dc.date.accessioned2010-12-08T09:49:00Z
dc.date.available2010-12-08T09:49:00Z
dc.date.issued1985-03
dc.identifier.citationEffect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells. 1985, 18 (2):193-9 Cell Tissue Kineten
dc.identifier.issn0008-8730
dc.identifier.pmid3882237
dc.identifier.urihttp://hdl.handle.net/10541/117405
dc.description.abstractAn inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure, 'Older' CFU-s (producing early spleen colonies) are more sensitive to stimulator, 'Younger' CFU-s (producing late spleen colonies) are more sensitive to inhibitor.
dc.language.isoenen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshAnimals
dc.subject.meshBone Marrow
dc.subject.meshBone Marrow Cells
dc.subject.meshCells, Cultured
dc.subject.meshCulture Media
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFemale
dc.subject.meshGrowth Substances
dc.subject.meshHematopoietic Cell Growth Factors
dc.subject.meshLymphokines
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshPhenylhydrazines
dc.subject.meshSpleen
dc.subject.meshStem Cells
dc.subject.meshTime Factors
dc.titleEffect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, The Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.en
dc.identifier.journalCell and Tissue Kineticsen
html.description.abstractAn inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure, 'Older' CFU-s (producing early spleen colonies) are more sensitive to stimulator, 'Younger' CFU-s (producing late spleen colonies) are more sensitive to inhibitor.


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