Effect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells.
AffiliationPaterson Laboratories, The Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, UK.
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AbstractAn inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure, 'Older' CFU-s (producing early spleen colonies) are more sensitive to stimulator, 'Younger' CFU-s (producing late spleen colonies) are more sensitive to inhibitor.
CitationEffect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells. 1985, 18 (2):193-9 Cell Tissue Kinet
JournalCell and Tissue Kinetics
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