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dc.contributor.authorTsubouchi, S
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-12-08T10:46:04Z
dc.date.available2010-12-08T10:46:04Z
dc.date.issued1985-09
dc.identifier.citationRecruitment of cells in the small intestine into rapid cell cycle by small doses of external gamma or internal beta-radiation. 1985, 48 (3):361-9 Int J Radiat Biol Relat Stud Phys Chem Meden
dc.identifier.issn0020-7616
dc.identifier.pmid3875577
dc.identifier.urihttp://hdl.handle.net/10541/117398
dc.description.abstractEpithelial cell recruitment was examined in mouse ileum after external gamma-irradiation (50 cGy) or internal beta-irradiation (0.148 MBq/g of [3H]thymidine), using the per cent-labelled-mitoses method and by analysing the distribution of mitotic cells in the crypts. In the presumptive stem cell zone at the lower cell positions of the crypt, the slowly cycling cells decreased their cell cycle 6 or 12 hours after a dose of 50 cGy. In the higher cell positions, a slight shortening of the cell cycle was also observed. After administration of a high dose of [3H]thymidine, dormant (G0) cells also entered the cell cycle in the lower cell positions. The results suggest that stem cells in the crypt may react to irradiation in two ways: first, by shortening the cell cycle in cycling cells; secondly, by an entry into the cell cycle by other dormant cells. There was destruction of some cycling stem cells before any recruitment. The data support the idea that the stem cell population in the crypt is heterogeneous.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshBeta Particles
dc.subject.meshCell Cycle
dc.subject.meshGamma Rays
dc.subject.meshIleum
dc.subject.meshInterphase
dc.subject.meshIntestinal Mucosa
dc.subject.meshMice
dc.subject.meshMitosis
dc.subject.meshStem Cells
dc.titleRecruitment of cells in the small intestine into rapid cell cycle by small doses of external gamma or internal beta-radiation.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, CHristie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicineen
html.description.abstractEpithelial cell recruitment was examined in mouse ileum after external gamma-irradiation (50 cGy) or internal beta-irradiation (0.148 MBq/g of [3H]thymidine), using the per cent-labelled-mitoses method and by analysing the distribution of mitotic cells in the crypts. In the presumptive stem cell zone at the lower cell positions of the crypt, the slowly cycling cells decreased their cell cycle 6 or 12 hours after a dose of 50 cGy. In the higher cell positions, a slight shortening of the cell cycle was also observed. After administration of a high dose of [3H]thymidine, dormant (G0) cells also entered the cell cycle in the lower cell positions. The results suggest that stem cells in the crypt may react to irradiation in two ways: first, by shortening the cell cycle in cycling cells; secondly, by an entry into the cell cycle by other dormant cells. There was destruction of some cycling stem cells before any recruitment. The data support the idea that the stem cell population in the crypt is heterogeneous.


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