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    Strain differences in the radiosensitivity of mouse spermatogonia.

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    Authors
    Bianchi, M
    Delic, Julian I
    Hurtado-de-Catalfo, G
    Hendry, Jolyon H
    Affiliation
    CERN, European Organisation for Nuclear Research, CH-1211, Geneve 23, Switzerland.
    Issue Date
    1985-10
    
    Metadata
    Show full item record
    Abstract
    The radiosensitivity of spermatogonia was found to be greater by up to a factor of 2 in C3H mice than in B6D2F1 mice, whether assessed for the highly sensitive spermatogonia (types A2 to In) or the much more resistant clonogenic spermatogonia which repopulate tubules. The latter were similarly resistant in the B6D2F1 hybrid and in the DBA2 parent, but were much more sensitive in the C57BL parent strain. A difference in sensitivity by up to a factor of 2 results in a variation by a factor of 10 or more in the level of survival of clonogenic cells after high doses. This variation is also observed when comparing data in the literature from different authors using various strains of mice. Using the radiosensitizer misonidazole, it was shown that hypoxia did not play a major role in the lesser sensitivity demonstrated in B6D2F1 mice. The variation in sensitivity is similar to the range reported in the literature for reciprocal translocations.
    Citation
    Strain differences in the radiosensitivity of mouse spermatogonia. 1985, 48 (4):579-88 Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
    Journal
    International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
    URI
    http://hdl.handle.net/10541/117397
    PubMed ID
    3876308
    Type
    Article
    Language
    en
    ISSN
    0020-7616
    Collections
    All Paterson Institute for Cancer Research

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