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dc.contributor.authorHendry, Jolyon H
dc.contributor.authorMoore, James V
dc.date.accessioned2010-12-08T10:22:40Z
dc.date.available2010-12-08T10:22:40Z
dc.date.issued1985-09
dc.identifier.citationDeriving absolute values of alpha and beta for dose fractionation, using dose-incidence data. 1985, 58 (693):885-90 Br J Radiolen
dc.identifier.issn0007-1285
dc.identifier.pmid3842291
dc.identifier.doi10.1259/0007-1285-58-693-885
dc.identifier.urihttp://hdl.handle.net/10541/117391
dc.description.abstractA method is described for calculating absolute "operational" values of the parameters alpha and beta that characterise dose fractionation data for tissues, by using the steepness of dose-incidence curves measured around each dose per fraction investigated. The values are deduced from published mouse lethality data after irradiation of the bone marrow (alpha = 0.9 Gy-1; beta = 0.06 Gy-2), the lung (alpha = 0.14 Gy-1; beta = 0.02 Gy-2), and the oesophagus (alpha = 0.06 Gy-1; beta = 0.004 Gy-2). With bone marrow and other hierarchical renewal tissues, the operational values apply also to the inactivation of target cells which are the stem cells in the tissue. For other tissue types the interpretation of the values is unknown. The operational values are useful in characterising the steepness of dose-incidence curves for normal tissue injury after different fractionation schedules.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Survival
dc.subject.meshMice
dc.subject.meshRadiation Dosage
dc.titleDeriving absolute values of alpha and beta for dose fractionation, using dose-incidence data.en
dc.typeArticleen
dc.contributor.departmentRadiobiology Section, Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalBritish Journal of Radiologyen
html.description.abstractA method is described for calculating absolute "operational" values of the parameters alpha and beta that characterise dose fractionation data for tissues, by using the steepness of dose-incidence curves measured around each dose per fraction investigated. The values are deduced from published mouse lethality data after irradiation of the bone marrow (alpha = 0.9 Gy-1; beta = 0.06 Gy-2), the lung (alpha = 0.14 Gy-1; beta = 0.02 Gy-2), and the oesophagus (alpha = 0.06 Gy-1; beta = 0.004 Gy-2). With bone marrow and other hierarchical renewal tissues, the operational values apply also to the inactivation of target cells which are the stem cells in the tissue. For other tissue types the interpretation of the values is unknown. The operational values are useful in characterising the steepness of dose-incidence curves for normal tissue injury after different fractionation schedules.


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