Deriving absolute values of alpha and beta for dose fractionation, using dose-incidence data.
AffiliationRadiobiology Section, Paterson Laboratories, CHristie Hospital and Holt Radium Institute, Manchester M20 9BX
MetadataShow full item record
AbstractA method is described for calculating absolute "operational" values of the parameters alpha and beta that characterise dose fractionation data for tissues, by using the steepness of dose-incidence curves measured around each dose per fraction investigated. The values are deduced from published mouse lethality data after irradiation of the bone marrow (alpha = 0.9 Gy-1; beta = 0.06 Gy-2), the lung (alpha = 0.14 Gy-1; beta = 0.02 Gy-2), and the oesophagus (alpha = 0.06 Gy-1; beta = 0.004 Gy-2). With bone marrow and other hierarchical renewal tissues, the operational values apply also to the inactivation of target cells which are the stem cells in the tissue. For other tissue types the interpretation of the values is unknown. The operational values are useful in characterising the steepness of dose-incidence curves for normal tissue injury after different fractionation schedules.
CitationDeriving absolute values of alpha and beta for dose fractionation, using dose-incidence data. 1985, 58 (693):885-90 Br J Radiol
JournalBritish Journal of Radiology
- The effect of fractionated doses of radiation on mouse spinal cord.
- Authors: Lo Y, Taylor JM, McBride WH, Withers HR
- Issue date: 1993 Sep 30
- The accelerated repopulation of a murine fibrosarcoma, FSA-II, during the fractionated irradiation and the linear-quadratic model.
- Authors: Abe Y, Urano M, Kenton LA, Kahn J, Willet CG
- Issue date: 1991 Nov
- Modification of radiation-induced damage to bone marrow stem cells by dose rate, dose fractionation, and prior exposure to cytoxan as judged by the survival of CFUs: application to bone marrow transplantation (BMT).
- Authors: Evans RG, Wheatley CL, Nielsen JR
- Issue date: 1988 Mar
- A review of alpha/beta ratios for experimental tumors: implications for clinical studies of altered fractionation.
- Authors: Williams MV, Denekamp J, Fowler JF
- Issue date: 1985 Jan
- Repair capacity of mouse lung after total body irradiation alone or combined with cyclophosphamide.
- Authors: Safwat A, Bentzen SM, Nielsen OS, Mahmoud HK, Overgaard J
- Issue date: 1996 Sep